Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)
1_MGIQG 6_ LLQFI 11_ KEASE 16_ PIHVR 21_ KYKGQ 26_ VVAVD 31_ TYCWL 36_ HKGAI 41_ ACAEK 46_ LAKGE 51_ PTDRY 56_ VGFCM 61_ KFVNM 66_ LLSHG 71_ IKPIL 76_ VFDGC 81_ TLPSK 86_ KEVER 91_ SRRER 96_ RQANL 101_ LKGKQ 106_ LLREG 111_ KVSEA 116_ RECFT 121_ RSINI 126_ THAMA 131_ HKVIK 136_ AARSQ 141_ GVDCL 146_ VAPYE 151_ ADAQL 156_ AYLNK 161_ AGIVQ 166_ AIITE 171_ DSDLL 176_ AFGCK 181_ KVILK 186_ MDQFG 191_ NGLEI 196_ DQARL 201_ GMCRQ 206_ LGDVF 211_ TEEKF 216_ RYMCI 221_ LSGCD 226_ YLSSL 231_ RGIGL 236_ AKACK 241_ VLRLA 246_ NNPDI 251_ VKVIK 256_ KIGHY 261_ LKMNI 266_ TVPED 271_ YINGF 276_ IRANN 281_ TFLYQ 286_ LVFDP 291_ IKRKL 296_ IPLNA 301_ YEDDV 306_ DPETL 311_ SYAGQ 316_ YVDDS 321_ IALQI 326_ ALGNK 331_ DINTF 336_ EQIDD 341_ YNPDT 346_ AMPAH 351_ SRSHS 356_ WDDKT 361_ CQKSA 366_ NVSSI 371_ WHRNY 376_ SPRPE 381_ SGTVS 386_ DAPQL 391_ KENPS 396_ TVGVE 401_ RVIST 406_ KGLNL 411_ PRKSS 416_ IVKRP 421_ RSAEL 426_ SEDDL 431_ LSQYS 436_ LSFTK 441_ KTKKN 446_ SSEGN 451_ KSLSF 456_ SEVFV 461_ PDLVN 466_ GPTNK 471_ KSVST 476_ PPRTR 481_ NKFAT 486_ FLQRK 491_ NEESG 496_ AVVVP 501_ GTRSR 506_ FFCSS 511_ DSTDC 516_ VSNKV 521_ SIQPL 526_ DETAV 531_ TDKEN 536_ NLHES 541_ EYGDQ 546_ EGKRL 551_ VDTDV 556_ ARNSS 561_ DDIPN 566_ NHIPG 571_ DHIPD 576_ KATVF 581_ TDEES 586_ YSFES 591_ SKFTR 596_ TISPP 601_ TLGTL 606_ RSCFS 611_ WSGGL 616_ GDFSR 621_ TPSPS 626_ PSTAL 631_ QQFRR 636_ KSDSP 641_ TSLPE 646_ NNMSD 651_ VSQLK 656_ SEESS 661_ DDESH 666_ PLREE 671_ ACSSQ 676_ SQESG 681_ EFSLQ 686_ SSNAS 691_ KLSQC 696_ SSKDS 701_ DSEES 706_ DCNIK 711_ LLDSQ 716_ SDQTS 721_ KLRLS 726_ HFSKK 731_ DTPLR 736_ NKVPG 741_ LYKSS 746_ SADSL 751_ STTKI 756_ KPLGP 761_ ARASG 766_ LSKKP 771_ ASIQK 776_ RKHHN 781_ AENKP 786_ GLQIK 791_ LNELW 796_ KNFGF 801_ KKDSE 806_ KLPPC 811_ KKPLS 816_ PVRDN 821_ IQLTP 826_ EAEED 831_ IFNKP 836_ ECGRV 841_QRAIF
1: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis