Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)
1_MSSPR 6_ AVVQL 11_ GKAQP 16_ AGEEL 21_ ATANQ 26_ TAQQP 31_ SSPAM 36_ RRLTV 41_ DDFEI 46_ GRPLG 51_ KGKFG 56_ NVYLA 61_ RLKES 66_ HFIVA 71_ LKVLF 76_ KSQIE 81_ KEGLE 86_ HQLRR 91_ EIEIQ 96_ AHLQH 101_ PNILR 106_ LYNYF 111_ HDARR 116_ VYLIL 121_ EYAPR 126_ GELYK 131_ ELQKS 136_ EKLDE 141_ QRTAT 146_ IIEEL 151_ ADALT 156_ YCHDK 161_ KVIHR 166_ DIKPE 171_ NLLLG 176_ FRGEV 181_ KIADF 186_ GWSVH 191_ TPSLR 196_ RKTMC 201_ GTLDY 206_ LPPEM 211_ IEGRT 216_ YDEKV 221_ DLWCI 226_ GVLCY 231_ ELLVG 236_ YPPFE 241_ SASHS 246_ ETYRR 251_ ILKVD 256_ VRFPL 261_ SMPLG 266_ ARDLI 271_ SRLLR 276_ YQPLE 281_ RLPLA 286_ QILKH 291_ PWVQA 296_ HSRRV 301_LPPCA
1: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'