GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
1_MSGGG 6_ DVVCT 11_ GWLRK 16_ SPPEK 21_ KLRRY 26_ AWKKR 31_ WFILR 36_ SGRMS 41_ GDPDV 46_ LEYYK 51_ NDHSK 56_ KPLRI 61_ INLNF 66_ CEQVD 71_ AGLTF 76_ NKKEL 81_ QDSFV 86_ FDIKT 91_ SERTF 96_ YLVAE 101_ TEEDM 106_ NKWVQ 111_ SICQI 116_ CGFNQ 121_ AEEST 126_ DSLRN 131_ VSSAG 136_ HGPRS 141_ SPAEL 146_ SSSSQ 151_ HLLRE 156_ RKSSA 161_ PSHSS 166_ QPTLF 171_ TFEPP 176_ VSNHM 181_ QPTLS 186_ TSAPQ 191_ EYLYL 196_ HQCIS 201_ RRAEN 206_ ARSAS 211_ FSQGT 216_ RASFL 221_ MRSDT 226_ AVQKL 231_ AQGNG 236_ HCVNG 241_ ISGQV 246_ HGFYS 251_ LPKPS 256_ RHNTE 261_ FRDST 266_ YDLPR 271_ SLASH 276_ GHTKG 281_ SLTGS 286_ ETDNE 291_ DVYTF 296_ KTPSN 301_ TLCRE 306_ FGDLL 311_ VDNMD 316_ VPATP 321_ LSAYQ 326_ IPRTF 331_ TLDKN 336_ HNAMT 341_ VATPG 346_ DSAIA 351_ PPPRP 356_ PKPSQ 361_ AETPR 366_ WGSPQ 371_ QRPPI 376_ SENSR 381_ SVAAT 386_ IPRRN 391_ TLPAM 396_ DNSRL 401_ HRASS 406_ CETYE 411_ YPQRG 416_ GESAG 421_ RSAES 426_ MSDGV 431_ GSFLP 436_ GKMIV 441_ GRSDS 446_ TNSED 451_ NYVPM 456_ NPGSS 461_ TLLAM 466_ ERAGD 471_ NSQSV 476_ YIPMS 481_ PGAHH 486_ FDSLG 491_ YPSTT 496_ LPVHR 501_ GPSRG 506_ SEIQP 511_ PPVNR 516_ NLKPD 521_ RKAKP 526_ TPLDL 531_ RNNTV 536_ IDELP 541_ FKSPI 546_ TKSWS 551_ RANHT 556_ FNSSS 561_ SQYCR 566_ PISTQ 571_ SITST 576_ DSGDS 581_ EENYV 586_ PMQNP 591_ VSASP 596_ VPSGT 601_ NSPAP 606_ KKSTG 611_ SVDYL 616_ ALDFQ 621_ PSSPS 626_ PHRKP 631_ STSSV 636_ TSDEK 641_ VDYVQ 646_ VDKEK 651_ TQALQ 656_ NTMQE 661_ WTDVR 666_ QSSEP 671_SKGAK
1: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis