Calcium-activated chloride channel regulator 2 (EC 3.4.-.-) (Calcium-activated chloride channel family member 2) (hCLCA2) (Calcium-activated chloride channel protein 3) (CaCC-3) (hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form]
1_MTQRS 6_ IAGPI 11_ CNLKF 16_ VTLLV 21_ ALSSE 26_ LPFLG 31_ AGVQL 36_ QDNGY 41_ NGLLI 46_ AINPQ 51_ VPENQ 56_ NLISN 61_ IKEMI 66_ TEASF 71_ YLFNA 76_ TKRRV 81_ FFRNI 86_ KILIP 91_ ATWKA 96_ NNNSK 101_ IKQES 106_ YEKAN 111_ VIVTD 116_ WYGAH 121_ GDDPY 126_ TLQYR 131_ GCGKE 136_ GKYIH 141_ FTPNF 146_ LLNDN 151_ LTAGY 156_ GSRGR 161_ VFVHE 166_ WAHLR 171_ WGVFD 176_ EYNND 181_ KPFYI 186_ NGQNQ 191_ IKVTR 196_ CSSDI 201_ TGIFV 206_ CEKGP 211_ CPQEN 216_ CIISK 221_ LFKEG 226_ CTFIY 231_ NSTQN 236_ ATASI 241_ MFMQS 246_ LSSVV 251_ EFCNA 256_ STHNQ 261_ EAPNL 266_ QNQMC 271_ SLRSA 276_ WDVIT 281_ DSADF 286_ HHSFP 291_ MNGTE 296_ LPPPP 301_ TFSLV 306_ QAGDK 311_ VVCLV 316_ LDVSS 321_ KMAEA 326_ DRLLQ 331_ LQQAA 336_ EFYLM 341_ QIVEI 346_ HTFVG 351_ IASFD 356_ SKGEI 361_ RAQLH 366_ QINSN 371_ DDRKL 376_ LVSYL 381_ PTTVS 386_ AKTDI 391_ SICSG 396_ LKKGF 401_ EVVEK 406_ LNGKA 411_ YGSVM 416_ ILVTS 421_ GDDKL 426_ LGNCL 431_ PTVLS 436_ SGSTI 441_ HSIAL 446_ GSSAA 451_ PNLEE 456_ LSRLT 461_ GGLKF 466_ FVPDI 471_ SNSNS 476_ MIDAF 481_ SRISS 486_ GTGDI 491_ FQQHI 496_ QLEST 501_ GENVK 506_ PHHQL 511_ KNTVT 516_ VDNTV 521_ GNDTM 526_ FLVTW 531_ QASGP 536_ PEIIL 541_ FDPDG 546_ RKYYT 551_ NNFIT 556_ NLTFR 561_ TASLW 566_ IPGTA 571_ KPGHW 576_ TYTLN 581_ NTHHS 586_ LQALK 591_ VTVTS 596_ RASNS 601_ AVPPA 606_ TVEAF 611_ VERDS 616_ LHFPH 621_ PVMIY 626_ ANVKQ 631_ GFYPI 636_ LNATV 641_ TATVE 646_ PETGD 651_ PVTLR 656_ LLDDG 661_ AGADV 666_ IKNDG 671_ IYSRY 676_ FFSFA 681_ ANGRY 686_ SLKVH 691_ VNHSP 696_ SISTP 701_ AHSIP 706_ GSHAM 711_ YVPGY 716_ TANGN 721_ IQMNA 726_ PRKSV 731_ GRNEE 736_ ERKWG 741_ FSRVS 746_ SGGSF 751_ SVLGV 756_ PAGPH 761_ PDVFP 766_ PCKII 771_ DLEAV 776_ KVEEE 781_ LTLSW 786_ TAPGE 791_ DFDQG 796_ QATSY 801_ EIRMS 806_ KSLQN 811_ IQDDF 816_ NNAIL 821_ VNTSK 826_ RNPQQ 831_ AGIRE 836_ IFTFS 841_ PQIST 846_ NGPEH 851_ QPNGE 856_ THESH 861_ RIYVA 866_ IRAMD 871_ RNSLQ 876_ SAVSN 881_ IAQAP 886_ LFIPP 891_ NSDPV 896_ PARDY 901_ LILKG 906_ VLTAM 911_ GLIGI 916_ ICLII 921_ VVTHH 926_ TLSRK 931_ KRADK 936_KENGT
1: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4