C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
1_MAERE 6_ SGGLG 11_ GGAAS 16_ PPAAS 21_ PFLGL 26_ HIASP 31_ PNFRL 36_ THDIS 41_ LEEFE 46_ DEDLS 51_ EITDE 56_ CGISL 61_ QCKDT 66_ LSLRP 71_ PRAGL 76_ LSAGG 81_ GGAGS 86_ RLQAE 91_ MLQMD 96_ LIDAT 101_ GDTPG 106_ AEDDE 111_ EDDDE 116_ ERAAR 121_ RPGAG 126_ PPKAE 131_ SGQEP 136_ ASRGQ 141_ GQSQG 146_ QSQGP 151_ GSGDT 156_ YRPKR 161_ PTTLN 166_ LFPQV 171_ PRSQD 176_ TLNNN 181_ SLGKK 186_ HSWQD 191_ RVSRS 196_ SSPLK 201_ TGEQT 206_ PPHEH 211_ ICLSD 216_ ELPPQ 221_ SGPAP 226_ TTDRG 231_ TSTDS 236_ PCRRS 241_ TATQM 246_ APPGG 251_ PPAAP 256_ PGGRG 261_ HSHRD 266_ RIHYQ 271_ ADVRL 276_ EATEE 281_ IYLTP 286_ VQRPP 291_ DAAEP 296_ TSAFL 301_ PPTES 306_ RMSVS 311_ SDPDP 316_ AAYPS 321_ TAGRP 326_ HPSIS 331_ EEEEG 336_ FDCLS 341_ SPERA 346_ EPPGG 351_ GWRGS 356_ LGEPP 361_ PPPRA 366_ SLSSD 371_ TSALS 376_ YDSVK 381_ YTLVV 386_ DEHAQ 391_ LELVS 396_ LRPCF 401_ GDYSD 406_ ESDSA 411_ TVYDN 416_ CASVS 421_ SPYES 426_ AIGEE 431_ YEEAP 436_ RPQPP 441_ ACLSE 446_ DSTPD 451_ EPDVH 456_ FSKKF 461_ LNVFM 466_ SGRSR 471_ SSSAE 476_ SFGLF 481_ SCIIN 486_ GEEQE 491_ QTHRA 496_ IFRFV 501_ PRHED 506_ ELELE 511_ VDDPL 516_ LVELQ 521_ AEDYW 526_ YEAYN 531_ MRTGA 536_ RGVFP 541_ AYYAI 546_ EVTKE 551_ PEHMA 556_ ALAKN 561_ SDWVD 566_ QFRVK 571_ FLGSV 576_ QVPYH 581_ KGNDV 586_ LCAAM 591_ QKIAT 596_ TRRLT 601_ VHFNP 606_ PSSCV 611_ LEISV 616_ RGVKI 621_ GVKAD 626_ DSQEA 631_ KGNKC 636_ SHFFQ 641_ LKNIS 646_ FCGYH 651_ PKNNK 656_ YFGFI 661_ TKHPA 666_ DHRFA 671_ CHVFV 676_ SEDST 681_ KALAE 686_ SVGRA 691_ FQQFY 696_ KQFVE 701_ YTCPT 706_EDIYL
1: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells