Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
1_MNSPN 6_ ESDGM 11_ SGREP 16_ SLEIL 21_ PRTSL 26_ HSIPV 31_ TVEVK 36_ PVLPR 41_ AMPSS 46_ MGGGG 51_ GGSPS 56_ PVELR 61_ GALVG 66_ SVDPT 71_ LREQQ 76_ LQQEL 81_ LALKQ 86_ QQQLQ 91_ KQLLF 96_ AEFQK 101_ QHDHL 106_ TRQHE 111_ VQLQK 116_ HLKQQ 121_ QEMLA 126_ AKQQQ 131_ EMLAA 136_ KRQQE 141_ LEQQR 146_ QREQQ 151_ RQEEL 156_ EKQRL 161_ EQQLL 166_ ILRNK 171_ EKSKE 176_ SAIAS 181_ TEVKL 186_ RLQEF 191_ LLSKS 196_ KEPTP 201_ GGLNH 206_ SLPQH 211_ PKCWG 216_ AHHAS 221_ LDQSS 226_ PPQSG 231_ PPGTP 236_ PSYKL 241_ PLPGP 246_ YDSRD 251_ DFPLR 256_ KTASE 261_ PNLKV 266_ RSRLK 271_ QKVAE 276_ RRSSP 281_ LLRRK 286_ DGTVI 291_ STFKK 296_ RAVEI 301_ TGAGP 306_ GASSV 311_ CNSAP 316_ GSGPS 321_ SPNSS 326_ HSTIA 331_ ENGFT 336_ GSVPN 341_ IPTEM 346_ LPQHR 351_ ALPLD 356_ SSPNQ 361_ FSLYT 366_ SPSLP 371_ NISLG 376_ LQATV 381_ TVTNS 386_ HLTAS 391_ PKLST 396_ QQEAE 401_ RQALQ 406_ SLRQG 411_ GTLTG 416_ KFMST 421_ SSIPG 426_ CLLGV 431_ ALEGD 436_ GSPHG 441_ HASLL 446_ QHVLL 451_ LEQAR 456_ QQSTL 461_ IAVPL 466_ HGQSP 471_ LVTGE 476_ RVATS 481_ MRTVG 486_ KLPRH 491_ RPLSR 496_ TQSSP 501_ LPQSP 506_ QALQQ 511_ LVMQQ 516_ QHQQF 521_ LEKQK 526_ QQQLQ 531_ LGKIL 536_ TKTGE 541_ LPRQP 546_ TTHPE 551_ ETEEE 556_ LTEQQ 561_ EVLLG 566_ EGALT 571_ MPREG 576_ STESE 581_ STQED 586_ LEEED 591_ EEDDG 596_ EEEED 601_ CIQVK 606_ DEEGE 611_ SGAEE 616_ GPDLE 621_ EPGAG 626_ YKKLF 631_ SDAQP 636_ LQPLQ 641_ VYQAP 646_ LSLAT 651_ VPHQA 656_ LGRTQ 661_ SSPAA 666_ PGGMK 671_ SPPDQ 676_ PVKHL 681_ FTTGV 686_ VYDTF 691_ MLKHQ 696_ CMCGN 701_ THVHP 706_ EHAGR 711_ IQSIW 716_ SRLQE 721_ TGLLS 726_ KCERI 731_ RGRKA 736_ TLDEI 741_ QTVHS 746_ EYHTL 751_ LYGTS 756_ PLNRQ 761_ KLDSK 766_ KLLGP 771_ ISQKM 776_ YAVLP 781_ CGGIG 786_ VDSDT 791_ VWNEM 796_ HSSSA 801_ VRMAV 806_ GCLLE 811_ LAFKV 816_ AAGEL 821_ KNGFA 826_ IIRPP 831_ GHHAE 836_ ESTAM 841_ GFCFF 846_ NSVAI 851_ TAKLL 856_ QQKLN 861_ VGKVL 866_ IVDWD 871_ IHHGN 876_ GTQQA 881_ FYNDP 886_ SVLYI 891_ SLHRY 896_ DNGNF 901_ FPGSG 906_ APEEV 911_ GGGPG 916_ VGYNV 921_ NVAWT 926_ GGVDP 931_ PIGDV 936_ EYLTA 941_ FRTVV 946_ MPIAH 951_ EFSPD 956_ VVLVS 961_ AGFDA 966_ VEGHL 971_ SPLGG 976_ YSVTA 981_ RCFGH 986_ LTRQL 991_ MTLAG 996_ GRVVL 1001_ ALEGG 1006_ HDLTA 1011_ ICDAS 1016_ EACVS 1021_ ALLSV 1026_ ELQPL 1031_ DEAVL 1036_ QQKPN 1041_ INAVA 1046_ TLEKV 1051_ IEIQS 1056_ KHWSC 1061_ VQKFA 1066_ AGLGR 1071_ SLREA 1076_ QAGET 1081_ EEAET 1086_ VSAMA 1091_ LLSVG 1096_ AEQAQ 1101_ AAAAR 1106_ EHSPR 1111_ PAEEP 1116_MEQEP
1: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758)