Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
1_MATIT 6_ CTRFT 11_ EEYQL 16_ FEELG 21_ KGAFS 26_ VVRRC 31_ VKVLA 36_ GQEYA 41_ AKIIN 46_ TKKLS 51_ ARDHQ 56_ KLERE 61_ ARICR 66_ LLKHP 71_ NIVRL 76_ HDSIS 81_ EEGHH 86_ YLIFD 91_ LVTGG 96_ ELFED 101_ IVARE 106_ YYSEA 111_ DASHC 116_ IQQIL 121_ EAVLH 126_ CHQMG 131_ VVHRD 136_ LKPEN 141_ LLLAS 146_ KLKGA 151_ AVKLA 156_ DFGLA 161_ IEVEG 166_ EQQAW 171_ FGFAG 176_ TPGYL 181_ SPEVL 186_ RKDPY 191_ GKPVD 196_ LWACG 201_ VILYI 206_ LLVGY 211_ PPFWD 216_ EDQHR 221_ LYQQI 226_ KAGAY 231_ DFPSP 236_ EWDTV 241_ TPEAK 246_ DLINK 251_ MLTIN 256_ PSKRI 261_ TAAEA 266_ LKHPW 271_ ISHRS 276_ TVASC 281_ MHRQE 286_ TVDCL 291_ KKFNA 296_ RRKLK 301_ GAILT 306_ TMLAT 311_ RNFSG 316_ GKSGG 321_ NKKSD 326_ GVKES 331_ SESTN 336_ TTIED 341_ EDTKV 346_ RKQEI 351_ IKVTE 356_ QLIEA 361_ ISNGD 366_ FESYT 371_ KMCDP 376_ GMTAF 381_ EPEAL 386_ GNLVE 391_ GLDFH 396_ RFYFE 401_ NLWSR 406_ NSKPV 411_ HTTIL 416_ NPHIH 421_ LMGDE 426_ SACIA 431_ YIRIT 436_ QYLDA 441_ GGIPR 446_ TAQSE 451_ ETRVW 456_ HRRDG 461_ KWQIV 466_ HFHRS 471_GAPSV
1: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)