Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)
1_MASLF 6_ KKKTV 11_ DDVIK 16_ EQNRE 21_ LRGTQ 26_ RAIIR 31_ DRAAL 36_ EKQEK 41_ QLELE 46_ IKKMA 51_ KIGNK 56_ EACKV 61_ LAKQL 66_ VHLRK 71_ QKTRT 76_ FAVSS 81_ KVTSM 86_ STQTK 91_ VMNSQ 96_ MKMAG 101_ AMSTT 106_ AKTMQ 111_ AVNKK 116_ MDPQK 121_ TLQTM 126_ QNFQK 131_ ENMKM 136_ EMTEE 141_ MINDT 146_ LDDIF 151_ DGSDD 156_ EEESQ 161_ DIVNQ 166_ VLDEI 171_ GIEIS 176_ GKMAK 181_ APSAA 186_ RSLPS 191_ ASTSK 196_ ATISD 201_ EEIER 206_QLKAL
1: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4