Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)
1_MPRQL 6_ SAAAA 11_ LFASL 16_ AVILH 21_ DGSQM 26_ RAKAF 31_ PETRD 36_ YSQPT 41_ AAATV 46_ QDIKK 51_ PVQQP 56_ AKQAP 61_ HQTLA 66_ ARFMD 71_ GHITF 76_ QTAAT 81_ VKIPT 86_ TTPAT 91_ TKNTA 96_ TTSPI 101_ TYTLV 106_ TTQAT 111_ PNNSH 116_ TAPPV 121_ TEVTV 126_ GPSLA 131_ PYSLP 136_ PTITP 141_ PAHTT 146_ GTSSS 151_ TVSHT 156_ TGNTT 161_ QPSNQ 166_ TTLPA 171_ TLSIA 176_ LHKST 181_ TGQKP 186_ VQPTH 191_ APGTT 196_ AAAHN 201_ TTRTA 206_ APAST 211_ VPGPT 216_ LAPQP 221_ SSVKT 226_ GIYQV 231_ LNGSR 236_ LCIKA 241_ EMGIQ 246_ LIVQD 251_ KESVF 256_ SPRRY 261_ FNIDP 266_ NATQA 271_ SGNCG 276_ TRKSN 281_ LLLNF 286_ QGGFV 291_ NLTFT 296_ KDEES 301_ YYISE 306_ VGAYL 311_ TVSDP 316_ ETIYQ 321_ GIKHA 326_ VVMFQ 331_ TAVGH 336_ SFKCV 341_ SEQSL 346_ QLSAH 351_ LQVKT 356_ TDVQL 361_ QAFDF 366_ EDDHF 371_ GNVDE 376_ CSSDY 381_ TIVLP 386_ VIGAI 391_ VVGLC 396_ LMGMG 401_ VYKIR 406_ LRCQS 411_SGYQR
1: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752)
2: (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection
3: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F
4: (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium