Endogenous retrovirus group K member 19 Pol protein (HERV-K(C19) Pol protein) (HERV-K_19q11 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
1_NKSKK 6_ RRNRV 11_ SFLGA 16_ ATVEP 21_ PKPIP 26_ LTWKT 31_ EKPVW 36_ VNQWP 41_ LPKQK 46_ LEALH 51_ LLANE 56_ QLEKG 61_ HIEPS 66_ FSPWN 71_ SPVFV 76_ IQKKS 81_ GKWRM 86_ LTDLR 91_ AVNAV 96_ NAVIQ 101_ PMGPL 106_ QPGLP 111_ SLAMI 116_ PKDWP 121_ LIIID 126_ LKDCF 131_ FTIPL 136_ AEQDC 141_ EKFAF 146_ TIPAI 151_ NNKEP 156_ ATRFQ 161_ WKVLP 166_ QGMLN 171_ SPTIC 176_ QTFVG 181_ RALQP 186_ VREKF 191_ SDCYI 196_ IHYID 201_ DILCA 206_ AEMKD 211_ KLIDC 216_ YTFLQ 221_ AEVAN 226_ AGLAI 231_ ASDKI 236_ QTSTP 241_ FHYLE 246_ MQIEN 251_ RKIKP 256_ PKIEI 261_ RKDTL 266_ KTLND 271_ FQKLL 276_ GDINW 281_ IRPTL 286_ GIPTY 291_ AMSNL 296_ FSILR 301_ GDSDL 306_ NSKRM 311_ LTPEA 316_ TKEIK 321_ LVEEK 326_ IQSAQ 331_ INRID 336_ PLAPL 341_ QLLIF 346_ ATAHS 351_ PTGII 356_ IQNTD 361_ LVEWS 366_ FLPHS 371_ TVKTF 376_ TLYLD 381_ QMATL 386_ IGQTR 391_ LRIIK 396_ LCGND 401_ PDKIV 406_ VPLTK 411_ EQVRQ 416_ AFINS 421_ GAWQI 426_ GLANF 431_ VGIID 436_ NHYPK 441_ TKIFQ 446_ FLKMT 451_ TWILP 456_ KITRR 461_ EPLEN 466_ ALTVF 471_ TDGSS 476_ NGKAA 481_ YTGPK 486_ ERVIK 491_ TQYQS 496_ AQRAE 501_ LVAVI 506_ TVLQD 511_ FDQPI 516_ NIISD 521_ SAYVV 526_ QATRD 531_ VETAL 536_ IKYSM 541_ DDQLN 546_ QLFNL 551_ LQQTV 556_ RKRNF 561_ PFYIT 566_ HIRAH 571_ TNLPG 576_ PLTKA 581_ NEQAD 586_ LLVSS 591_ ALIKA 596_ QELHA 601_ LTHVN 606_ VAGLK 611_ NKFDV 616_ TWKQA 621_ KDIVQ 626_ HCTQC 631_ QVLHL 636_ PTQEA 641_ GVNPR 646_ GLCPN 651_ ALWQM 656_ DVTHV 661_ SSFGR 666_ LSYIH 671_ VTVDT 676_ YSHFI 681_ WATCQ 686_ TGEST 691_ SHVKK 696_ HLLSC 701_ FAVMG 706_ VPEKI 711_ KTDNG 716_ PGYCS 721_ KAFQK 726_ FLSQW 731_ KISHT 736_ TGIPY 741_ NSQGQ 746_ AIVER 751_ TNRTL 756_ KTQLV 761_ KQKEG 766_ GDSKE 771_ CTTPQ 776_ MQLNL 781_ ALYTL 786_ NFLNI 791_ YRNQT 796_ TTSAE 801_ QHLTG 806_ KKNSP 811_ HEGKL 816_ IWWKD 821_ NKNKT 826_ WEIGK 831_ VITWG 836_ RGFAC 841_ VSPGE 846_ NQLPV 851_ WIPTR 856_ HLKFY 861_ NEPIG 866_ DAKKS 871_ TSAET 876_ ETPQS 881_ STVDS 886_ QDEQN 891_ GDVRR 896_ TDEVA 901_ IHQES 906_ RAADL 911_ GTTKE 916_ ADAVS 921_ YKISR 926_ EHKGD 931_ TNPRE 936_ YAACG 941_ LDDCI 946_ NGGKS 951_PYACR
1: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution