Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)
1_MSQSP 6_ AFGPR 11_ RGSSP 16_ RGAAG 21_ AAARR 26_ NESQD 31_ YLLMD 36_ SELGE 41_ DGCPQ 46_ APLPC 51_ YGYYP 56_ CFRGS 61_ DNRLA 66_ HRRQT 71_ VLREK 76_ GRRLA 81_ NRGPA 86_ YMFSD 91_ RSTSL 96_ SIEEE 101_ RFLDA 106_ AEYGN 111_ IPVVR 116_ KMLEE 121_ CHSLN 126_ VNCVD 131_ YMGQN 136_ ALQLA 141_ VANEH 146_ LEITE 151_ LLLKK 156_ ENLSR 161_ VGDAL 166_ LLAIS 171_ KGYVR 176_ IVEAI 181_ LSHPA 186_ FAEGK 191_ RLATS 196_ PSQSE 201_ LQQDD 206_ FYAYD 211_ EDGTR 216_ FSHDV 221_ TPIIL 226_ AAHCQ 231_ EYEIV 236_ HTLLR 241_ KGARI 246_ ERPHD 251_ YFCKC 256_ NDCNQ 261_ KQKHD 266_ SFSHS 271_ RSRIN 276_ AYKGL 281_ ASPAY 286_ LSLSS 291_ EDPVM 296_ TALEL 301_ SNELA 306_ VLANI 311_ EKEFK 316_ NDYKK 321_ LSMQC 326_ KDFVV 331_ GLLDL 336_ CRNTE 341_ EVEAI 346_ LNGDV 351_ ETLQS 356_ GDHGR 361_ PNLSR 366_ LKLAI 371_ KYEVK 376_ KFVAH 381_ PNCQQ 386_ QLLSI 391_ WYENL 396_ SGLRQ 401_ QTMAV 406_ KFLVV 411_ LAVAI 416_ GLPFL 421_ ALIYW 426_ FAPCS 431_ KMGKI 436_ MRGPF 441_ MKFVA 446_ HAASF 451_ TIFLG 456_ LLVMN 461_ AADRF 466_ EGTKL 471_ LPNET 476_ STDNA 481_ KQLFR 486_ MKTSC 491_ FSWME 496_ MLIIS 501_ WVIGM 506_ IWAEC 511_ KEIWT 516_ QGPKE 521_ YLFEL 526_ WNMLD 531_ FGMLA 536_ IFAAS 541_ FIARF 546_ MAFWH 551_ ASKAQ 556_ SIIDA 561_ NDTLK 566_ DLTKV 571_ TLGDN 576_ VKYYN 581_ LARIK 586_ WDPSD 591_ PQIIS 596_ EGLYA 601_ IAVVL 606_ SFSRI 611_ AYILP 616_ ANESF 621_ GPLQI 626_ SLGRT 631_ VKDIF 636_ KFMVI 641_ FIMVF 646_ VAFMI 651_ GMFNL 656_ YSYYI 661_ GAKQN 666_ EAFTT 671_ VEESF 676_ KTLFW 681_ AIFGL 686_ SEVKS 691_ VVINY 696_ NHKFI 701_ ENIGY 706_ VLYGV 711_ YNVTM 716_ VIVLL 721_ NMLIA 726_ MINSS 731_ FQEIE 736_ DDADV 741_ EWKFA 746_ RAKLW 751_ FSYFE 756_ EGRTL 761_ PVPFN 766_ LVPSP 771_ KSLFY 776_ LLLKL 781_ KKWIS 786_ ELFQG 791_ HKKGF 796_ QEDAE 801_ MNKIN 806_ EEKKL 811_ GILGS 816_ HEDLS 821_ KLSLD 826_ KKQVG 831_ HNKQP 836_ SIRSS 841_ EDFHL 846_ NSFNN 851_ PPRQY 856_ QKIMK 861_ RLIKR 866_ YVLQA 871_ QIDKE 876_ SDEVN 881_ EGELK 886_ EIKQD 891_ ISSLR 896_ YELLE 901_ EKSQN 906_ TEDLA 911_ ELIRE 916_ LGEKL 921_ SMEPN 926_QEETN
1: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion