Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
1_MEHIR 6_ TTKVE 11_ QVKLL 16_ DRFST 21_ SNKSL 26_ TGTLY 31_ LTATH 36_ LLFID 41_ SHQKE 46_ TWILH 51_ HHIAS 56_ VEKLA 61_ LTTSG 66_ CPLVI 71_ QCKNF 76_ RTVHF 81_ IVPRE 86_ RDCHD 91_ IYNSL 96_ LQLSK 101_ QAKYE 106_ DLYAF 111_ SYNPK 116_ QNDSE 121_ RLQGW 126_ QLIDL 131_ AEEYK 136_ RMGVP 141_ NSHWQ 146_ LSDAN 151_ RDYKI 156_ CETYP 161_ RELYV 166_ PRIAS 171_ KPIIV 176_ GSSKF 181_ RSKGR 186_ FPVLS 191_ YYHQD 196_ KEAAI 201_ CRCSQ 206_ PLSGF 211_ SARCL 216_ EDEHL 221_ LQAIS 226_ KANPV 231_ NRYMY 236_ VMDTR 241_ PKLNA 246_ MANRA 251_ AGKGY 256_ ENEDN 261_ YSNIR 266_ FQFVG 271_ IENIH 276_ VMRSS 281_ LQKLL 286_ EVNGT 291_ KGLSV 296_ NDFYS 301_ GLESS 306_ GWLRH 311_ IKAVM 316_ DAAIF 321_ LAKAI 326_ TVENA 331_ SVLVH 336_ CSDGW 341_ DRTSQ 346_ VCSLG 351_ SLLLD 356_ SYYRT 361_ IKGFM 366_ VLIEK 371_ DWISF 376_ GHKFS 381_ ERCGQ 386_ LDGDP 391_ KEVSP 396_ VFTQF 401_ LECVW 406_ HLTEQ 411_ FPQAF 416_ EFSEA 421_ FLLQI 426_ HEHIH 431_ SCQFG 436_ NFLGN 441_ CQKER 446_ EELKL 451_ KEKTY 456_ SLWPF 461_ LLEDQ 466_ KKYLN 471_ PLYSS 476_ ESHRF 481_ TVLEP 486_ NTVSF 491_ NFKFW 496_ RNMYH 501_ QFDRT 506_ LHPRQ 511_ SVFNI 516_ IMNMN 521_ EQNKQ 526_ LEKDI 531_ KDLES 536_ KIKQR 541_ KNKQT 546_ DGILT 551_ KELLH 556_ SVHPE 561_ SPNLK 566_ TSLCF 571_ KEQTL 576_ LPVND 581_ ALRTI 586_ EGSSP 591_ ADNRY 596_ SEYAE 601_ EFSKS 606_ EPAVV 611_ SLEYG 616_VARMT
1: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:19038970, PubMed:22647598). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970)