Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc-2-epimerase/ManAc kinase) [Includes: UDP-N-acetylglucosamine 2-epimerase (hydrolyzing) (EC 3.2.1.183) (UDP-GlcNAc-2-epimerase) (Uridine diphosphate-N-acetylglucosamine-2-epimerase); N-acetylmannosamine kinase (EC 2.7.1.60) (ManAc kinase)]
1_MEKNG 6_ NNRKL 11_ RVCVA 16_ TCNRA 21_ DYSKL 26_ APIMF 31_ GIKTE 36_ PEFFE 41_ LDVVV 46_ LGSHL 51_ IDDYG 56_ NTYRM 61_ IEQDD 66_ FDINT 71_ RLHTI 76_ VRGED 81_ EAAMV 86_ ESVGL 91_ ALVKL 96_ PDVLN 101_ RLKPD 106_ IMIVH 111_ GDRFD 116_ ALALA 121_ TSAAL 126_ MNIRI 131_ LHIEG 136_ GEVSG 141_ TIDDS 146_ IRHAI 151_ TKLAH 156_ YHVCC 161_ TRSAE 166_ QHLIS 171_ MCEDH 176_ DRILL 181_ AGCPS 186_ YDKLL 191_ SAKNK 196_ DYMSI 201_ IRMWL 206_ GDDVK 211_ SKDYI 216_ VALQH 221_ PVTTD 226_ IKHSI 231_ KMFEL 236_ TLDAL 241_ ISFNK 246_ RTLVL 251_ FPNID 256_ AGSKE 261_ MVRVM 266_ RKKGI 271_ EHHPN 276_ FRAVK 281_ HVPFD 286_ QFIQL 291_ VAHAG 296_ CMIGN 301_ SSCGV 306_ REVGA 311_ FGTPV 316_ INLGT 321_ RQIGR 326_ ETGEN 331_ VLHVR 336_ DADTQ 341_ DKILQ 346_ ALHLQ 351_ FGKQY 356_ PCSKI 361_ YGDGN 366_ AVPRI 371_ LKFLK 376_ SIDLQ 381_ EPLQK 386_ KFCFP 391_ PVKEN 396_ ISQDI 401_ DHILE 406_ TLSAL 411_ AVDLG 416_ GTNLR 421_ VAIVS 426_ MKGEI 431_ VKKYT 436_ QFNPK 441_ TYEER 446_ INLIL 451_ QMCVE 456_ AAAEA 461_ VKLNC 466_ RILGV 471_ GISTG 476_ GRVNP 481_ REGIV 486_ LHSTK 491_ LIQEW 496_ NSVDL 501_ RTPLS 506_ DTLHL 511_ PVWVD 516_ NDGNC 521_ AALAE 526_ RKFGQ 531_ GKGLE 536_ NFVTL 541_ ITGTG 546_ IGGGI 551_ IHQHE 556_ LIHGS 561_ SFCAA 566_ ELGHL 571_ VVSLD 576_ GPDCS 581_ CGSHG 586_ CIEAY 591_ ASGMA 596_ LQREA 601_ KKLHD 606_ EDLLL 611_ VEGMS 616_ VPKDE 621_ AVGAL 626_ HLIQA 631_ AKLGN 636_ AKAQS 641_ ILRTA 646_ GTALG 651_ LGVVN 656_ ILHTM 661_ NPSLV 666_ ILSGV 671_ LASHY 676_ IHIVK 681_ DVIRQ 686_ QALSS 691_ VQDVD 696_ VVVSD 701_ LVDPA 706_ LLGAA 711_ SMVLD 716_YTTRR
1: Bifunctional enzyme that possesses both UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation, playing a role in embryonic angiogenesis (PubMed:10334995, PubMed:11326336, PubMed:14707127, PubMed:16503651, PubMed:2808337, PubMed:38237079). Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition (PubMed:10334995, PubMed:14707127)