Solute carrier family 22 member 13 (Organic cation transporter-like 3) (ORCTL-3)
1_MAQFV 6_ QVLAE 11_ IGDFG 16_ RFQIQ 21_ LLILL 26_ CVLNF 31_ LSPFY 36_ FFAHV 41_ FMVLD 46_ EPHHC 51_ AVAWV 56_ KNHTF 61_ NLSAA 66_ EQLVL 71_ SVPLD 76_ TAGHP 81_ EPCLM 86_ FRPPP 91_ ANASL 96_ QDILS 101_ HRFNE 106_ TQPCD 111_ MGWEY 116_ PENRL 121_ PSLKN 126_ EFNLV 131_ CDRKH 136_ LKDTT 141_ QSVFM 146_ AGLLV 151_ GTLMF 156_ GPLCD 161_ RIGRK 166_ ATILA 171_ QLLLF 176_ TLIGL 181_ ATAFV 186_ PSFEL 191_ YMALR 196_ FAVAT 201_ AVAGL 206_ SFSNV 211_ TLLTE 216_ WVGPS 221_ WRTQA 226_ VVLAQ 231_ CNFSL 236_ GQMVL 241_ AGLAY 246_ GFRNW 251_ RLLQI 256_ TGTAP 261_ GLLLF 266_ FYFWA 271_ LPESA 276_ RWLLT 281_ RGRMD 286_ EAIQL 291_ IQKAA 296_ SVNRR 301_ KLSPE 306_ LMNQL 311_ VPEKT 316_ GPSGN 321_ ALDLF 326_ RHPQL 331_ RKVTL 336_ IIFCV 341_ WFVDS 346_ LGYYG 351_ LSLQV 356_ GDFGL 361_ DVYLT 366_ QLIFG 371_ AVEVP 376_ ARCSS 381_ IFMMQ 386_ RFGRK 391_ WSQLG 396_ TLVLG 401_ GLMCI 406_ IIIFI 411_ PADLP 416_ VVVTM 421_ LAVVG 426_ KMATA 431_ AAFTI 436_ SYVYS 441_ AELFP 446_ TILRQ 451_ TGMGL 456_ VGIFS 461_ RIGGI 466_ LTPLV 471_ ILLGE 476_ YHAAL 481_ PMLIY 486_ GSLPI 491_ VAGLL 496_ CTLLP 501_ ETHGQ 506_ GLKDT 511_ LQDLE 516_ LGPHP 521_ RSPKS 526_ VPSEK 531_ ETEAK 536_ GRTSS 541_ PGVAF 546_VSSTY
1: Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:31780526, PubMed:35144162, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:31780526, PubMed:35144162). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable)