Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42)
1_MGRIG 6_ ISCLF 11_ PASWH 16_ FSISP 21_ VGCPR 26_ ILNTN 31_ LRQIM 36_ VISVL 41_ AAAVS 46_ LLYFS 51_ VVIIR 56_ NKYGR 61_ LTRDK 66_ KFQRY 71_ LARVT 76_ DIEAT 81_ DTNNP 86_ NVNYG 91_ IVVDC 96_ GSSGS 101_ RVFVY 106_ CWPRH 111_ NGNPH 116_ DLLDI 121_ RQMRD 126_ KNRKP 131_ VVMKI 136_ KPGIS 141_ EFATS 146_ PEKVS 151_ DYISP 156_ LLNFA 161_ AEHVP 166_ RAKHK 171_ ETPLY 176_ ILCTA 181_ GMRIL 186_ PESQQ 191_ KAILE 196_ DLLTD 201_ IPVHF 206_ DFLFS 211_ DSHAE 216_ VISGK 221_ QEGVY 226_ AWIGI 231_ NFVLG 236_ RFEHI 241_ EDDDE 246_ AVVEV 251_ NIPGS 256_ ESSEA 261_ IVRKR 266_ TAGIL 271_ DMGGV 276_ STQIA 281_ YEVPK 286_ TVSFA 291_ SSQQE 296_ EVAKN 301_ LLAEF 306_ NLGCD 311_ VHQTE 316_ HVYRV 321_ YVATF 326_ LGFGG 331_ NAARQ 336_ RYEDR 341_ IFANT 346_ IQKNR 351_ LLGKQ 356_ TGLTP 361_ DMPYL 366_ DPCLP 371_ LDIKD 376_ EIQQN 381_ GQTIY 386_ LRGTG 391_ DFDLC 396_ RETIQ 401_ PFMNK 406_ TNETQ 411_ TSLNG 416_ VYQPP 421_ IHFQN 426_ SEFYG 431_ FSEFY 436_ YCTED 441_ VLRMG 446_ GDYNA 451_ AKFTK 456_ AAKDY 461_ CATKW 466_ SILRE 471_ RFDRG 476_ LYASH 481_ ADLHR 486_ LKYQC 491_ FKSAW 496_ MFEVF 501_ HRGFS 506_ FPVNY 511_ KSLKT 516_ ALQVY 521_ DKEVQ 526_ WTLGA 531_ ILYRT 536_ RFLPL 541_ RDIQQ 546_ EAFRA 551_ SHTHW 556_ RGVSF 561_ VYNHY 566_ LFSGC 571_ FLVVL 576_ LAILL 581_ YLLRL 586_ RRIHR 591_ RTPRS 596_ SSAAA 601_ LWMEE 606_ GLPAQ 611_NAPGT
1: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452)
2: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally