TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3)
1_MISPD 6_ PRPSP 11_ GLARW 16_ AESYE 21_ AKCER 26_ RQEIR 31_ ESRRC 36_ RPNVT 41_ TCRQV 46_ GKTLR 51_ IQQRE 56_ QLQRA 61_ RLQQF 66_ FRRRN 71_ LELEE 76_ KGKAQ 81_ HPQAR 86_ EQGPS 91_ RRPGQ 96_ VTVLK 101_ EPLSC 106_ ARRIS 111_ SPREQ 116_ VTGTS 121_ SEVFP 126_ AQHPP 131_ PSGIC 136_ RDLSD 141_ HLSSQ 146_ AGGLP 151_ PQDTP 156_ IKKPP 161_ KHHRG 166_ TQTKA 171_ EGPTI 176_ KNDAS 181_ QQTNY 186_ GVAVL 191_ DKEII 196_ QLSDY 201_ LKEAL 206_ QRELV 211_ LKQKM 216_ VILQD 221_ LLSTL 226_ IQASD 231_ SSWKG 236_ QLNED 241_ KLKGK 246_ LRSLE 251_ NQLYT 256_ CTQKY 261_ SPWGM 266_ KKVLL 271_ EMEDQ 276_ KNSYE 281_ QKAKE 286_ SLQKV 291_ LEEKM 296_ NAEQQ 301_ LQSTQ 306_ RSLAL 311_ AEQKC 316_ EEWRS 321_ QYEAL 326_ KEDWR 331_ TLGTQ 336_ HRELE 341_ SQLHV 346_ LQSKL 351_ QGADS 356_ RDLQM 361_ NQALR 366_ FLENE 371_ HQQLQ 376_ AKIEC 381_ LQGDR 386_ DLCSL 391_ DTQDL 396_ QDQLK 401_ RSEAE 406_ KLTLV 411_ TRVQQ 416_ LQGLL 421_ QNQSL 426_ QLQEQ 431_ EKLLT 436_ KKDQA 441_ LPVWS 446_ PKSFP 451_ NEVEP 456_ EGTGK 461_ EKDWD 466_ LRDQL 471_ QKKTL 476_ QLQAK 481_ EKECR 486_ ELHSE 491_ LDNLS 496_ DEYLS 501_ CLRKL 506_ QHCRE 511_ ELNQS 516_ QQLPP 521_ RRQCG 526_ RWLPV 531_ LMVVI 536_ AAALA 541_ VFLAN 546_KDNLM
1: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851)