4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (EC 2.4.1.152) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase)
1_MTSTS 6_ KGILR 11_ PFLIV 16_ CIILG 21_ CFMAC 26_ LLIYI 31_ KPTNS 36_ WIFSP 41_ MESAS 46_ SVLKM 51_ KNFFS 56_ TKTDY 61_ FNETT 66_ ILVWV 71_ WPFGQ 76_ TFDLT 81_ SCQAM 86_ FNIQG 91_ CHLTT 96_ DRSLY 101_ NKSHA 106_ VLIHH 111_ RDISW 116_ DLTNL 121_ PQQAR 126_ PPFQK 131_ WIWMN 136_ LESPT 141_ HTPQK 146_ SGIEH 151_ LFNLT 156_ LTYRR 161_ DSDIQ 166_ VPYGF 171_ LTVST 176_ NPFVF 181_ EVPSK 186_ EKLVC 191_ WVVSN 196_ WNPEH 201_ ARVKY 206_ YNELS 211_ KSIEI 216_ HTYGQ 221_ AFGEY 226_ VNDKN 231_ LIPTI 236_ STCKF 241_ YLSFE 246_ NSIHK 251_ DYITE 256_ KLYNA 261_ FLAGS 266_ VPVVL 271_ GPSRE 276_ NYENY 281_ IPADS 286_ FIHVE 291_ DYNSP 296_ SELAK 301_ YLKEV 306_ DKNNK 311_ LYLSY 316_ FNWRK 321_ DFTVN 326_ LPRFW 331_ ESHAC 336_ LACDH 341_ VKRHQ 346_ EYKSV 351_GNLEK
1: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (PubMed:10386598, PubMed:10622713, PubMed:11278338, PubMed:12107078, PubMed:16282604, PubMed:17335083, PubMed:18395013, PubMed:23192350, PubMed:23263199, PubMed:29593094, PubMed:37202521). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity) (PubMed:17335083, PubMed:23000574). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:23192350). Can also modify milk oligosaccharides, in particular type 2 tetrasaccharide LNnT (PubMed:37202521)