cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17)
1_MRIEE 6_ RKSQH 11_ LTGLT 16_ DEKVK 21_ AYLSL 26_ HPQVL 31_ DEFVS 36_ ESVSA 41_ ETVEK 46_ WLKRK 51_ NNKSE 56_ DESAP 61_ KEVSR 66_ YQDTN 71_ MQGVV 76_ YELNS 81_ YIEQR 86_ LDTGG 91_ DNQLL 96_ LYELS 101_ SIIKI 106_ ATKAD 111_ GFALY 116_ FLGEC 121_ NNSLC 126_ IFTPP 131_ GIKEG 136_ KPRLI 141_ PAGPI 146_ TQGTT 151_ VSAYV 156_ AKSRK 161_ TLLVE 166_ DILGD 171_ ERFPR 176_ GTGLE 181_ SGTRI 186_ QSVLC 191_ LPIVT 196_ AIGDL 201_ IGILE 206_ LYRHW 211_ GKEAF 216_ CLSHQ 221_ EVATA 226_ NLAWA 231_ SVAIH 236_ QVQVC 241_ RGLAK 246_ QTELN 251_ DFLLD 256_ VSKTY 261_ FDNIV 266_ AIDSL 271_ LEHIM 276_ IYAKN 281_ LVNAD 286_ RCALF 291_ QVDHK 296_ NKELY 301_ SDLFD 306_ IGEEK 311_ EGKPV 316_ FKKTK 321_ EIRFS 326_ IEKGI 331_ AGQVA 336_ RTGEV 341_ LNIPD 346_ AYADP 351_ RFNRE 356_ VDLYT 361_ GYTTR 366_ NILCM 371_ PIVSR 376_ GSVIG 381_ VVQMV 386_ NKISG 391_ SAFSK 396_ TDENN 401_ FKMFA 406_ VFCAL 411_ ALHCA 416_ NMYHR 421_ IRHSE 426_ CIYRV 431_ TMEKL 436_ SYHSI 441_ CTSEE 446_ WQGLM 451_ QFTLP 456_ VRLCK 461_ EIELF 466_ HFDIG 471_ PFENM 476_ WPGIF 481_ VYMVH 486_ RSCGT 491_ SCFEL 496_ EKLCR 501_ FIMSV 506_ KKNYR 511_ RVPYH 516_ NWKHA 521_ VTVAH 526_ CMYAI 531_ LQNNH 536_ TLFTD 541_ LERKG 546_ LLIAC 551_ LCHDL 556_ DHRGF 561_ SNSYL 566_ QKFDH 571_ PLAAL 576_ YSTST 581_ MEQHH 586_ FSQTV 591_ SILQL 596_ EGHNI 601_ FSTLS 606_ SSEYE 611_ QVLEI 616_ IRKAI 621_ IATDL 626_ ALYFG 631_ NRKQL 636_ EEMYQ 641_ TGSLN 646_ LNNQS 651_ HRDRV 656_ IGLMM 661_ TACDL 666_ CSVTK 671_ LWPVT 676_ KLTAN 681_ DIYAE 686_ FWAEG 691_ DEMKK 696_ LGIQP 701_ IPMMD 706_ RDKKD 711_ EVPQG 716_ QLGFY 721_ NAVAI 726_ PCYTT 731_ LTQIL 736_ PPTEP 741_ LLKAC 746_ RDNLS 751_ QWEKV 756_ IRGEE 761_ TATWI 766_ SSPSV 771_AQKAA
1: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447)