RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
1_MSDVT 6_ IVKEG 11_ WVQKR 16_ GEYIK 21_ NWRPR 26_ YFLLK 31_ TDGSF 36_ IGYKE 41_ KPQDV 46_ DLPYP 51_ LNNFS 56_ VAKCQ 61_ LMKTE 66_ RPKPN 71_ TFIIR 76_ CLQWT 81_ TVIER 86_ TFHVD 91_ TPEER 96_ EEWTE 101_ AIQAV 106_ ADRLQ 111_ RQEEE 116_ RMNCS 121_ PTSQI 126_ DNIGE 131_ EEMDA 136_ STTHH 141_ KRKTM 146_ NDFDY 151_ LKLLG 156_ KGTFG 161_ KVILV 166_ REKAS 171_ GKYYA 176_ MKILK 181_ KEVII 186_ AKDEV 191_ AHTLT 196_ ESRVL 201_ KNTRH 206_ PFLTS 211_ LKYSF 216_ QTKDR 221_ LCFVM 226_ EYVNG 231_ GELFF 236_ HLSRE 241_ RVFSE 246_ DRTRF 251_ YGAEI 256_ VSALD 261_ YLHSG 266_ KIVYR 271_ DLKLE 276_ NLMLD 281_ KDGHI 286_ KITDF 291_ GLCKE 296_ GITDA 301_ ATMKT 306_ FCGTP 311_ EYLAP 316_ EVLED 321_ NDYGR 326_ AVDWW 331_ GLGVV 336_ MYEMM 341_ CGRLP 346_ FYNQD 351_ HEKLF 356_ ELILM 361_ EDIKF 366_ PRTLS 371_ SDAKS 376_ LLSGL 381_ LIKDP 386_ NKRLG 391_ GGPDD 396_ AKEIM 401_ RHSFF 406_ SGVNW 411_ QDVYD 416_ KKLVP 421_ PFKPQ 426_ VTSET 431_ DTRYF 436_ DEEFT 441_ AQTIT 446_ ITPPE 451_ KYDED 456_ GMDCM 461_ DNERR 466_ PHFPQ 471_FSYSA
1: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis