DNA replication complex GINS protein PSF2 (GINS complex subunit 2)
1_MDAAE 6_ VEFLA 11_ EKELV 16_ TIIPN 21_ FSLDK 26_ IYLIG 31_ GDLGP 36_ FNPGL 41_ PVEVP 46_ LWLAI 51_ NLKQR 56_ QKCRL 61_ LPPEW 66_ MDVEK 71_ LEKMR 76_ DHERK 81_ EETFT 86_ PMPSP 91_ YYMEL 96_ TKLLL 101_ NHASD 106_ NIPKA 111_ DEIRT 116_ LVKDM 121_ WDTRI 126_ AKLRV 131_ SADSF 136_ VRQQE 141_ AHAKL 146_ DNLTL 151_ MEINT 156_ SGTFL 161_ TQALN 166_ HMYKL 171_ RTNLQ 176_PLEST
1: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232)