Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]
1_MLLRS 6_ KPALP 11_ PPLML 16_ LLLGP 21_ LGPLS 26_ PGALP 31_ RPAQA 36_ QDVVD 41_ LDFFT 46_ QEPLH 51_ LVSPS 56_ FLSVT 61_ IDANL 66_ ATDPR 71_ FLILL 76_ GSPKL 81_ RTLAR 86_ GLSPA 91_ YLRFG 96_ GTKTD 101_ FLIFD 106_ PKKES 111_ TFEER 116_ SYWQS 121_ QVNQD 126_ ICKYG 131_ SIPPD 136_ VEEKL 141_ RLEWP 146_ YQEQL 151_ LLREH 156_ YQKKF 161_ KNSTY 166_ SRSSV 171_ DVLYT 176_ FANCS 181_ GLDLI 186_ FGLNA 191_ LLRTA 196_ DLQWN 201_ SSNAQ 206_ LLLDY 211_ CSSKG 216_ YNISW 221_ ELGNE 226_ PNSFL 231_ KKADI 236_ FINGS 241_ QLGED 246_ FIQLH 251_ KLLRK 256_ STFKN 261_ AKLYG 266_ PDVGQ 271_ PRRKT 276_ AKMLK 281_ SFLKA 286_ GGEVI 291_ DSVTW 296_ HHYYL 301_ NGRTA 306_ TKEDF 311_ LNPDV 316_ LDIFI 321_ SSVQK 326_ VFQVV 331_ ESTRP 336_ GKKVW 341_ LGETS 346_ SAYGG 351_ GAPLL 356_ SDTFA 361_ AGFMW 366_ LDKLG 371_ LSARM 376_ GIEVV 381_ MRQVF 386_ FGAGN 391_ YHLVD 396_ ENFDP 401_ LPDYW 406_ LSLLF 411_ KKLVG 416_ TKVLM 421_ ASVQG 426_ SKRRK 431_ LRVYL 436_ HCTNT 441_ DNPRY 446_ KEGDL 451_ TLYAI 456_ NLHNV 461_ TKYLR 466_ LPYPF 471_ SNKQV 476_ DKYLL 481_ RPLGP 486_ HGLLS 491_ KSVQL 496_ NGLTL 501_ KMVDD 506_ QTLPP 511_ LMEKP 516_ LRPGS 521_ SLGLP 526_ AFSYS 531_ FFVIR 536_NAKVA
1: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis