E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF6)
1_MNQSR 6_ SRSDG 11_ GSEET 16_ LPQDH 21_ NHHEN 26_ ERRWQ 31_ QERLH 36_ REEAY 41_ YQFIN 46_ ELNDE 51_ DYRLM 56_ RDHNL 61_ LGTPG 66_ EITSE 71_ ELQQR 76_ LDGVK 81_ EQLAS 86_ QPDLR 91_ DGTNY 96_ RDSEV 101_ PRESS 106_ HEDSL 111_ LEWLN 116_ TFRRT 121_ GNATR 126_ SGQNG 131_ NQTWR 136_ AVSRT 141_ NPNNG 146_ EFRFS 151_ LEIHV 156_ NHENR 161_ GFEIH 166_ GEDYT 171_ DIPLS 176_ DSNRD 181_ HTANR 186_ QQRST 191_ SPVAR 196_ RTRSQ 201_ TSVNF 206_ NGSSS 211_ NIPRT 216_ RLASR 221_ GQNPA 226_ EGSFS 231_ TLGRL 236_ RNGIG 241_ GAAGI 246_ PRANA 251_ SRTNF 256_ SSHTN 261_ QSGGS 266_ ELRQR 271_ EGQRF 276_ GAAHV 281_ WENGA 286_ RSNVT 291_ VRNTN 296_ QRLEP 301_ IRLRS 306_ TSNSR 311_ SRSPI 316_ QRQSG 321_ TVYHN 326_ SQRES 331_ RPVQQ 336_ TTRRS 341_ VRRRG 346_ RTRVF 351_ LEQDR 356_ ERERR 361_ GTAYT 366_ PFSNS 371_ RLVSR 376_ ITVEE 381_ GEESS 386_ RSSTA 391_ VRRHP 396_ TITLD 401_ LQVRR 406_ IRPGE 411_ NRDRD 416_ SIANR 421_ TRSRV 426_ GLAEN 431_ TVTIE 436_ SNSGG 441_ FRRTI 446_ SRLER 451_ SGIRT 456_ YVSTI 461_ TVPLR 466_ RISEN 471_ ELVEP 476_ SSVAL 481_ RSILR 486_ QIMTG 491_ FGELS 496_ SLMEA 501_ DSESE 506_ LQRNG 511_ QHLPD 516_ MHSEL 521_ SNLGT 526_ DNNRS 531_ QHREG 536_ SSQDR 541_ QAQGD 546_ STEMH 551_ GENET 556_ TQPHT 561_ RNSDS 566_ RGGRQ 571_ LRNPN 576_ NLVET 581_ GTLPI 586_ LRLAH 591_ FFLLN 596_ ESDDD 601_ DRIRG 606_ LTKEQ 611_ IDNLS 616_ TRHYE 621_ HNSID 626_ SELGK 631_ ICSVC 636_ ISDYV 641_ TGNKL 646_ RQLPC 651_ MHEFH 656_ IHCID 661_ RWLSE 666_ NCTCP 671_ ICRQP 676_VLGSN
1: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (PubMed:19345326). May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity)