PRELI domain-containing protein 1, mitochondrial (25 kDa protein of relevant evolutionary and lymphoid interest) (Px19-like protein)
1_MVKYF 6_ LGQSV 11_ LRSSW 16_ DQVFA 21_ AFWQR 26_ YPNPY 31_ SKHVL 36_ TEDIV 41_ HREVT 46_ PDQKL 51_ LSRRL 56_ LTKTN 61_ RMPRW 66_ AERLF 71_ PANVA 76_ HSVYV 81_ LEDSI 86_ VDPQN 91_ QTMTT 96_ FTWNI 101_ NHARL 106_ MVVEE 111_ RCVYC 116_ VNSDN 121_ SGWTE 126_ IRREA 131_ WVSSS 136_ LFGVS 141_ RAVQE 146_ FGLAR 151_ FKSNV 156_ TKTMK 161_ GFEYI 166_ LAKLQ 171_ GEAPS 176_ KTLVE 181_ TAKEA 186_ KEKAK 191_ ETALA 196_ ATEKA 201_ KDLAS 206_ KAATK 211_KQQQQ
1: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs