CAAX prenyl protease 2 (EC 3.4.-.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1)
1_MAALG 6_ GDGLR 11_ LLSVS 16_ RPERP 21_ PESAA 26_ LGGLG 31_ PGLCC 36_ WVSVF 41_ SCLSL 46_ ACSYV 51_ GSLYV 56_ WKSEL 61_ PRDHP 66_ AVIKR 71_ RFTSV 76_ LVVSS 81_ LSPLC 86_ VLLWR 91_ ELTGI 96_ QPGTS 101_ LLTLM 106_ GFRLE 111_ GIFPA 116_ ALLPL 121_ LLTMI 126_ LFLGP 131_ LMQLS 136_ MDCPC 141_ DLADG 146_ LKVVL 151_ APRSW 156_ ARCLT 161_ DMRWL 166_ RNQVI 171_ APLTE 176_ ELVFR 181_ ACMLP 186_ MLAPC 191_ MGLGP 196_ AVFTC 201_ PLFFG 206_ VAHFH 211_ HIIEQ 216_ LRFRQ 221_ SSVGN 226_ IFLSA 231_ AFQFS 236_ YTAVF 241_ GAYTA 246_ FLFIR 251_ TGHLI 256_ GPVLC 261_ HSFCN 266_ YMGFP 271_ AVCAA 276_ LEHPQ 281_ RRPLL 286_ AGYAL 291_ GVGLF 296_ LLLLQ 301_ PLTDP 306_ KLYGS 311_ LPLCV 316_ LLERA 321_GDSEA
1: Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068)