Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
1_MRRGA 6_ LLAGA 11_ LAAYA 16_ AYLVL 21_ GALLV 26_ ARLEG 31_ PHEAR 36_ LRAEL 41_ ETLRA 46_ QLLQR 51_ SPCVA 56_ APALD 61_ AFVER 66_ VLAAG 71_ RLGRV 76_ VLANA 81_ SGSAN 86_ ASDPA 91_ WDFAS 96_ ALFFA 101_ STLIT 106_ TVGYG 111_ YTTPL 116_ TDAGK 121_ AFSIA 126_ FALLG 131_ VPTTM 136_ LLLTA 141_ SAQRL 146_ SLLLT 151_ HVPLS 156_ WLSMR 161_ WGWDP 166_ RRAAC 171_ WHLVA 176_ LLGVV 181_ VTVCF 186_ LVPAV 191_ IFAHL 196_ EEAWS 201_ FLDAF 206_ YFCFI 211_ SLSTI 216_ GLGDY 221_ VPGEA 226_ PGQPY 231_ RALYK 236_ VLVTV 241_ YLFLG 246_ LVAMV 251_ LVLQT 256_ FRHVS 261_ DLHGL 266_ TELIL 271_ LPPPC 276_ PASFN 281_ ADEDD 286_ RVDIL 291_ GPQPE 296_ SHQQL 301_ SASSH 306_TDYAS
1: K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity)
2: Does not display channel activity