Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B)
1_MLGAV 6_ KMEGH 11_ EPSDW 16_ SSYYA 21_ EPEGY 26_ SSVSN 31_ MNAGL 36_ GMNGM 41_ NTYMS 46_ MSAAA 51_ MGSGS 56_ GNMSA 61_ GSMNM 66_ SSYVG 71_ AGMSP 76_ SLAGM 81_ SPGAG 86_ AMAGM 91_ GGSAG 96_ AAGVA 101_ GMGPH 106_ LSPSL 111_ SPLGG 116_ QAAGA 121_ MGGLA 126_ PYANM 131_ NSMSP 136_ MYGQA 141_ GLSRA 146_ RDPKT 151_ YRRSY 156_ THAKP 161_ PYSYI 166_ SLITM 171_ AIQQS 176_ PNKML 181_ TLSEI 186_ YQWIM 191_ DLFPF 196_ YRQNQ 201_ QRWQN 206_ SIRHS 211_ LSFND 216_ CFLKV 221_ PRSPD 226_ KPGKG 231_ SFWTL 236_ HPDSG 241_ NMFEN 246_ GCYLR 251_ RQKRF 256_ KCEKQ 261_ LALKE 266_ AAGAA 271_ GSGKK 276_ AAAGA 281_ QASQA 286_ QLGEA 291_ AGPAS 296_ ETPAG 301_ TESPH 306_ SSASP 311_ CQEHK 316_ RGGLG 321_ ELKGT 326_ PAAAL 331_ SPPEP 336_ APSPG 341_ QQQQA 346_ AAHLL 351_ GPPHH 356_ PGLPP 361_ EAHLK 366_ PEHHY 371_ AFNHP 376_ FSINN 381_ LMSSE 386_ QQHHH 391_ SHHHH 396_ QPHKM 401_ DLKAY 406_ EQVMH 411_ YPGYG 416_ SPMPG 421_ SLAMG 426_ PVTNK 431_ TGLDA 436_ SPLAA 441_ DTSYY 446_ QGVYS 451_RPIMN
1: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation