Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)
1_MSYPA 6_ DDYES 11_ EAAYD 16_ PYAYP 21_ SDYDM 26_ HTGDP 31_ KQDLA 36_ YERQY 41_ EQQTY 46_ QVIPE 51_ VIKNF 56_ IQYFH 61_ KTVSD 66_ LIDQK 71_ VYELQ 76_ ASRVS 81_ SDVID 86_ QKVYE 91_ IQDIY 96_ ENSWT 101_ KLTER 106_ FFKNT 111_ PWPEA 116_ EAIAP 121_ QVGND 126_ AVFLI 131_ LYKEL 136_ YYRHI 141_ YAKVS 146_ GGPSL 151_ EQRFE 156_ SYYNY 161_ CNLFN 166_ YILNA 171_ DGPAP 176_ LELPN 181_ QWLWD 186_ IIDEF 191_ IYQFQ 196_ SFSQY 201_ RCKTA 206_ KKSEE 211_ EIDFL 216_ RSNPK 221_ IWNVH 226_ SVLNV 231_ LHSLV 236_ DKSNI 241_ NRQLE 246_ VYTSG 251_ GDPES 256_ VAGEY 261_ GRHSL 266_ YKMLG 271_ YFSLV 276_ GLLRL 281_ HSLLG 286_ DYYQA 291_ IKVLE 296_ NIELN 301_ KKSMY 306_ SRVPE 311_ CQVTT 316_ YYYVG 321_ FAYLM 326_ MRRYQ 331_ DAIRV 336_ FANIL 341_ LYIQR 346_ TKSMF 351_ QRTTY 356_ KYEMI 361_ NKQNE 366_ QMHAL 371_ LAIAL 376_ TMYPM 381_ RIDES 386_ IHLQL 391_ REKYG 396_ DKMLR 401_ MQKGD 406_ PQVYE 411_ ELFSY 416_ SCPKF 421_ LSPVV 426_ PNYDN 431_ VHPNY 436_ HKEPF 441_ LQQLK 446_ VFSDE 451_ VQQQA 456_ QLSTI 461_ RSFLK 466_ LYTTM 471_ PVAKL 476_ AGFLD 481_ LTEQE 486_ FRIQL 491_ LVFKH 496_ KMKNL 501_ VWTSG 506_ ISALD 511_ GEFQS 516_ ASEVD 521_ FYIDK 526_ DMIHI 531_ ADTKV 536_ ARRYG 541_ DFFIR 546_ QIHKF 551_ EELNR 556_TLKKM
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
2: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)