Phospholipase A-2-activating protein (PLA2P) (PLAP)
1_MTSGA 6_ TRYRL 11_ SCSLR 16_ GHELD 21_ VRGLV 26_ CCAYP 31_ PGAFV 36_ SVSRD 41_ RTTRL 46_ WAPDS 51_ PNRSF 56_ TEMHC 61_ MSGHS 66_ NFVSC 71_ VCIIP 76_ SSDIY 81_ PHGLI 86_ ATGGN 91_ DHNIC 96_ IFSLD 101_ SPMPL 106_ YILKG 111_ HKNTV 116_ CSLSS 121_ GKFGT 126_ LLSGS 131_ WDTTA 136_ KVWLN 141_ DKCMM 146_ TLQGH 151_ TAAVW 156_ AVKIL 161_ PEQGL 166_ MLTGS 171_ ADKTV 176_ KLWKA 181_ GRCER 186_ TFSGH 191_ EDCVR 196_ GLAIL 201_ SETEF 206_ LSCAN 211_ DASIR 216_ RWQIT 221_ GECLE 226_ VYYGH 231_ TNYIY 236_ SISVF 241_ PNCRD 246_ FVTTA 251_ EDRSL 256_ RIWKH 261_ GECAQ 266_ TIRLP 271_ AQSIW 276_ CCCVL 281_ DNGDI 286_ VVGAS 291_ DGIIR 296_ VFTES 301_ EDRTA 306_ SAEEI 311_ KAFEK 316_ ELSHA 321_ TIDSK 326_ TGDLG 331_ DINAE 336_ QLPGR 341_ EHLNE 346_ PGTRE 351_ GQTRL 356_ IRDGE 361_ KVEAY 366_ QWSVS 371_ EGRWI 376_ KIGDV 381_ VGSSG 386_ ANQQT 391_ SGKVL 396_ YEGKE 401_ FDYVF 406_ SIDVN 411_ EGGPS 416_ YKLPY 421_ NTSDD 426_ PWLTA 431_ YNFLQ 436_ KNDLN 441_ PMFLD 446_ QVAKF 451_ IIDNT 456_ KGQML 461_ GLGNP 466_ SFSDP 471_ FTGGG 476_ RYVPG 481_ SSGSS 486_ NTLPT 491_ ADPFT 496_ GAGRY 501_ VPGSA 506_ SMGTT 511_ MAGVD 516_ PFTGN 521_ SAYRS 526_ AASKT 531_ MNIYF 536_ PKKEA 541_ VTFDQ 546_ ANPTQ 551_ ILGKL 556_ KELNG 561_ TAPEE 566_ KKLTE 571_ DDLIL 576_ LEKIL 581_ SLICN 586_ SSSEK 591_ PTVQQ 596_ LQILW 601_ KAINC 606_ PEDIV 611_ FPALD 616_ ILRLS 621_ IKHPS 626_ VNENF 631_ CNEKE 636_ GAQFS 641_ SHLIN 646_ LLNPK 651_ GKPAN 656_ QLLAL 661_ RTFCN 666_ CFVGQ 671_ AGQKL 676_ MMSQR 681_ ESLMS 686_ HAIEL 691_ KSGSN 696_ KNIHI 701_ ALATL 706_ ALNYS 711_ VCFHK 716_ DHNIE 721_ GKAQC 726_ LSLIS 731_ TILEV 736_ VQDLE 741_ ATFRL 746_ LVALG 751_ TLISD 756_ DSNAV 761_ QLAKS 766_ LGVDS 771_ QIKKY 776_ SSVSE 781_ PAKVS 786_ECCRF
1: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986)