RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
1_MKIEE 6_ VKSTT 11_ KTQRI 16_ ASHSH 21_ VKGLG 26_ LDESG 31_ LAKQA 36_ ASGLV 41_ GQENA 46_ REACG 51_ VIVEL 56_ IKSKK 61_ MAGRA 66_ VLLAG 71_ PPGTG 76_ KTALA 81_ LAIAQ 86_ ELGSK 91_ VPFCP 96_ MVGSE 101_ VYSTE 106_ IKKTE 111_ VLMEN 116_ FRRAI 121_ GLRIK 126_ ETKEV 131_ YEGEV 136_ TELTP 141_ CETEN 146_ PMGGY 151_ GKTIS 156_ HVIIG 161_ LKTAK 166_ GTKQL 171_ KLDPS 176_ IFESL 181_ QKERV 186_ EAGDV 191_ IYIEA 196_ NSGAV 201_ KRQGR 206_ CDTYA 211_ TEFDL 216_ EAEEY 221_ VPLPK 226_ GDVHK 231_ KKEII 236_ QDVTL 241_ HDLDV 246_ ANARP 251_ QGGQD 256_ ILSMM 261_ GQLMK 266_ PKKTE 271_ ITDKL 276_ RGEIN 281_ KVVNK 286_ YIDQG 291_ IAELV 296_ PGVLF 301_ VDEVH 306_ MLDIE 311_ CFTYL 316_ HRALE 321_ SSIAP 326_ IVIFA 331_ SNRGN 336_ CVIRG 341_ TEDIT 346_ SPHGI 351_ PLDLL 356_ DRVMI 361_ IRTML 366_ YTPQE 371_ MKQII 376_ KIRAQ 381_ TEGIN 386_ ISEEA 391_ LNHLG 396_ EIGTK 401_ TTLRY 406_ SVQLL 411_ TPANL 416_ LAKIN 421_ GKDSI 426_ EKEHV 431_ EEISE 436_ LFYDA 441_ KSSAK 446_ ILADQ 451_QDKYM
1: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). Essential for cell proliferation (PubMed:14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681)