Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81)
1_MDETG 6_ NLTVS 11_ SATCH 16_ DTIDD 21_ FRNQV 26_ YSTLY 31_ SMISV 36_ VGFFG 41_ NGFVL 46_ YVLIK 51_ TYHKK 56_ SAFQV 61_ YMINL 66_ AVADL 71_ LCVCT 76_ LPLRV 81_ VYYVH 86_ KGIWL 91_ FGDFL 96_ CRLST 101_ YALYV 106_ NLYCS 111_ IFFMT 116_ AMSFF 121_ RCIAI 126_ VFPVQ 131_ NINLV 136_ TQKKA 141_ RFVCV 146_ GIWIF 151_ VILTS 156_ SPFLM 161_ AKPQK 166_ DEKNN 171_ TKCFE 176_ PPQDN 181_ QTKNH 186_ VLVLH 191_ YVSLF 196_ VGFII 201_ PFVII 206_ IVCYT 211_ MIILT 216_ LLKKS 221_ MKKNL 226_ SSHKK 231_ AIGMI 236_ MVVTA 241_ AFLVS 246_ FMPYH 251_ IQRTI 256_ HLHFL 261_ HNETK 266_ PCDSV 271_ LRMQK 276_ SVVIT 281_ LSLAA 286_ SNCCF 291_ DPLLY 296_ FFSGG 301_ NFRKR 306_ LSTFR 311_ KHSLS 316_ SVTYV 321_ PRKKA 326_ SLPEK 331_GEEIC
1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4