Type 2 lactosamine alpha-2,3-sialyltransferase (EC 2.4.99.-) (CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI) (ST3Gal VI) (ST3GalVI) (Sialyltransferase 10)
1_MRGYL 6_ VAIFL 11_ SAVFL 16_ YYVLH 21_ CILWG 26_ TNVYW 31_ VAPVE 36_ MKRRN 41_ KIQPC 46_ LSKPA 51_ FASLL 56_ RFHQF 61_ HPFLC 66_ AADFR 71_ KIASL 76_ YGSDK 81_ FDLPY 86_ GMRTS 91_ AEYFR 96_ LALSK 101_ LQSCD 106_ LFDEF 111_ DNIPC 116_ KKCVV 121_ VGNGG 126_ VLKNK 131_ TLGEK 136_ IDSYD 141_ VIIRM 146_ NNGPV 151_ LGHEE 156_ EVGRR 161_ TTFRL 166_ FYPES 171_ VFSDP 176_ IHNDP 181_ NTTVI 186_ LTAFK 191_ PHDLR 196_ WLLEL 201_ LMGDK 206_ INTNG 211_ FWKKP 216_ ALNLI 221_ YKPYQ 226_ IRILD 231_ PFIIR 236_ TAAYE 241_ LLHFP 246_ KVFPK 251_ NQKPK 256_ HPTTG 261_ IIAIT 266_ LAFYI 271_ CHEVH 276_ LAGFK 281_ YNFSD 286_ LKSPL 291_ HYYGN 296_ ATMSL 301_ MNKNA 306_ YHNVT 311_ AEQLF 316_ LKDII 321_ EKNLV 326_INLTQ
1: Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids (PubMed:10206952, PubMed:26692484). It's alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen (PubMed:10206952, PubMed:26692484). Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes (By similarity)