Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
1_MDDST 6_ EREQS 11_ RLTSC 16_ LKKRE 21_ EMKLK 26_ ECVSI 31_ LPRKE 36_ SPSVR 41_ SSKDG 46_ KLLAA 51_ TLLLA 56_ LLSCC 61_ LTVVS 66_ FYQVA 71_ ALQGD 76_ LASLR 81_ AELQG 86_ HHAEK 91_ LPAGA 96_ GAPKA 101_ GLEEA 106_ PAVTA 111_ GLKIF 116_ EPPAP 121_ GEGNS 126_ SQNSR 131_ NKRAV 136_ QGPEE 141_ TVTQD 146_ CLQLI 151_ ADSET 156_ PTIQK 161_ GSYTF 166_ VPWLL 171_ SFKRG 176_ SALEE 181_ KENKI 186_ LVKET 191_ GYFFI 196_ YGQVL 201_ YTDKT 206_ YAMGH 211_ LIQRK 216_ KVHVF 221_ GDELS 226_ LVTLF 231_ RCIQN 236_ MPETL 241_ PNNSC 246_ YSAGI 251_ AKLEE 256_ GDELQ 261_ LAIPR 266_ ENAQI 271_ SLDGD 276_VTFFG
1: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response
2: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity
3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis