Gene name: HS3ST2

Uniprot entry:

Q9Y278

Protein names:

Heparan sulfate glucosamine 3-O-sulfotransferase 2 (EC 2.8.2.29) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2) (3-OST-2) (Heparan sulfate 3-O-sulfotransferase 2) (h3-OST-2)

Protein sequence:

1_MAYRV 6_ LGRAG 11_ PPQPR 16_ RARRL 21_ LFAFT 26_ LSLSC 31_ TYLCY 36_ SFLCC 41_ CDDLG 46_ RSRLL 51_ GAPRC 56_ LRGPS 61_ AGGQK 66_ LLQKS 71_ RPCDP 76_ SGPTP 81_ SEPSA 86_ PSAPA 91_ AAVPA 96_ PRLSG 101_ SNHSG 106_ SPKLG 111_ TKRLP 116_ QALIV 121_ GVKKG 126_ GTRAV 131_ LEFIR 136_ VHPDV 141_ RALGT 146_ EPHFF 151_ DRNYG 156_ RGLDW 161_ YRSLM 166_ PRTLE 171_ SQITL 176_ EKTPS 181_ YFVTQ 186_ EAPRR 191_ IFNMS 196_ RDTKL 201_ IVVVR 206_ NPVTR 211_ AISDY 216_ TQTLS 221_ KKPDI 226_ PTFEG 231_ LSFRN 236_ RTLGL 241_ VDVSW 246_ NAIRI 251_ GMYVL 256_ HLESW 261_ LQYFP 266_ LAQIH 271_ FVSGE 276_ RLITD 281_ PAGEM 286_ GRVQD 291_ FLGIK 296_ RFITD 301_ KHFYF 306_ NKTKG 311_ FPCLK 316_ KTESS 321_ LLPRC 326_ LGKSK 331_ GRTHV 336_ QIDPE 341_ VIDQL 346_ REFYR 351_ PYNIK 356_ FYETV 361_GQDFR

Protein annotations

Protein functions:

1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:9988768). Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (PubMed:9988768). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768)