Cofilin-2 (Cofilin, muscle isoform)
1_MASGV 6_ TVNDE 11_ VIKVF 16_ NDMKV 21_ RKSST 26_ QEEIK 31_ KRKKA 36_ VLFCL 41_ SDDKR 46_ QIIVE 51_ EAKQI 56_ LVGDI 61_ GDTVE 66_ DPYTS 71_ FVKLL 76_ PLNDC 81_ RYALY 86_ DATYE 91_ TKESK 96_ KEDLV 101_ FIFWA 106_ PESAP 111_ LKSKM 116_ IYASS 121_ KDAIK 126_ KKFTG 131_ IKHEW 136_ QVNGL 141_ DDIKD 146_ RSTLG 151_ EKLGG 156_ NVVVS 161_LEGKP
1: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity)