Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)
1_MNKSE 6_ NLLFA 11_ GSSLA 16_ SQVHA 21_ AAVNG 26_ DKGAL 31_ QRLIV 36_ GNSAL 41_ KDKED 46_ QFGRT 51_ PLMYC 56_ VLADR 61_ LDCAD 66_ ALLKA 71_ GADVN 76_ KTDHS 81_ QRTAL 86_ HLAAQ 91_ KGNYR 96_ FMKLL 101_ LTRRA 106_ NWMQK 111_ DLEEM 116_ TPLHL 121_ TTRHR 126_ SPKCL 131_ ALLLK 136_ FMAPG 141_ EVDTQ 146_ DKNKQ 151_ TALHW 156_ SAYYN 161_ NPEHV 166_ KLLIK 171_ HDSNI 176_ GIPDV 181_ EGKIP 186_ LHWAA 191_ NHKDP 196_ SAVHT 201_ VRCIL 206_ DAAPT 211_ ESLLN 216_ WQDYE 221_ GRTPL 226_ HFAVA 231_ DGNVT 236_ VVDVL 241_ TSYES 246_ CNITS 251_ YDNLF 256_ RTPLH 261_ WAALL 266_ GHAQI 271_ VHLLL 276_ ERNKS 281_ GTIPS 286_ DSQGA 291_ TPLHY 296_ AAQSN 301_ FAETV 306_ KVFLK 311_ HPSVK 316_ DDSDL 321_ EGRTS 326_ FMWAA 331_ GKGSD 336_ DVLRT 341_ MLSLK 346_ SDIDI 351_ NMADK 356_ YGGTA 361_ LHAAA 366_ LSGHV 371_ STVKL 376_ LLENN 381_ AQVDA 386_ TDVMK 391_ HTPLF 396_ RACEM 401_ GHKDV 406_ IQTLI 411_ KGGAR 416_ VDLVD 421_ QDGHS 426_ LLHWA 431_ ALGGN 436_ ADVCQ 441_ ILIEN 446_ KINPN 451_ VQDYA 456_ GRTPL 461_ QCAAY 466_ GGYIN 471_ CMAVL 476_ MENNA 481_ DPNIQ 486_ DKEGR 491_ TALHW 496_ SCNNG 501_ YLDAI 506_ KLLLD 511_ FAAFP 516_ NQMEN 521_ NEERY 526_ TPLDY 531_ ALLGE 536_ RHEVI 541_ QFMLE 546_ HGALS 551_ IAAIQ 556_ DIAAF 561_ KIQAV 566_ YKGYK 571_ VRKAF 576_ RDRKN 581_ LLMKH 586_ EQLRK 591_ DAAAK 596_ KREEE 601_ NKRKE 606_ AEQQK 611_ GRRSP 616_ DSCRP 621_ QALPC 626_ LPSTQ 631_ DVPSR 636_ QSRAP 641_ SKQPP 646_ AGNVA 651_ QGPEP 656_ RDSRG 661_ SPGGS 666_ LGGAL 671_ QKEQH 676_ VSSDL 681_ QGTNS 686_ RRPNE 691_ TAREH 696_ SKGQS 701_ ACVHF 706_ RPNEG 711_ SDGSR 716_ HPGVP 721_ SVEKS 726_ RGETA 731_ GDERC 736_ AKGKG 741_ FVKQP 746_ SCIRV 751_ AGPDE 756_ KGEDS 761_ RRAAA 766_ SLPPH 771_ DSHWK 776_ PSRRH 781_ DTEPK 786_ AKCAP 791_ QKRRT 796_ QELRG 801_ GRCSP 806_ AGSSR 811_ PGSAR 816_ GEAVH 821_ AGQNP 826_ PHHRT 831_ PRNKV 836_ TQAKL 841_ TGGLY 846_ SHLPQ 851_ STEEL 856_ RSGAR 861_ RLETS 866_ TLSED 871_ FQVSK 876_ ETDPA 881_ PGPLS 886_ GQSVN 891_ IDLLP 896_ VELRL 901_ QIIQR 906_ ERRRK 911_ ELFRK 916_ KNKAA 921_ AVIQR 926_ AWRSY 931_ QLRKH 936_ LSHLR 941_ HMKQL 946_ GAGDV 951_ DRWRQ 956_ ESTAL 961_ LLQVW 966_ RKELE 971_ LKFPQ 976_ TTAVS 981_ KAPKS 986_ PSKGT 991_ SGTKS 996_ TKHSV 1001_ LKQIY 1006_ GCSHE 1011_ GKIHH 1016_ PTRSV 1021_ KASSV 1026_ LRLNS 1031_ VSNLQ 1036_ CIHLL 1041_ ENSGR 1046_ SKNFS 1051_ YNLQS 1056_ATQPK
1: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity)