Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
1_MLLLL 6_ LLPLL 11_ WGRER 16_ VEGQK 21_ SNRKD 26_ YSLTM 31_ QSSVT 36_ VQEGM 41_ CVHVR 46_ CSFSY 51_ PVDSQ 56_ TDSDP 61_ VHGYW 66_ FRAGN 71_ DISWK 76_ APVAT 81_ NNPAW 86_ AVQEE 91_ TRDRF 96_ HLLGD 101_ PQTKN 106_ CTLSI 111_ RDARM 116_ SDAGR 121_ YFFRM 126_ EKGNI 131_ KWNYK 136_ YDQLS 141_ VNVTA 146_ LTHRP 151_ NILIP 156_ GTLES 161_ GCFQN 166_ LTCSV 171_ PWACE 176_ QGTPP 181_ MISWM 186_ GTSVS 191_ PLHPS 196_ TTRSS 201_ VLTLI 206_ PQPQH 211_ HGTSL 216_ TCQVT 221_ LPGAG 226_ VTTNR 231_ TIQLN 236_ VSYPP 241_ QNLTV 246_ TVFQG 251_ EGTAS 256_ TALGN 261_ SSSLS 266_ VLEGQ 271_ SLRLV 276_ CAVDS 281_ NPPAR 286_ LSWTW 291_ RSLTL 296_ YPSQP 301_ SNPLV 306_ LELQV 311_ HLGDE 316_ GEFTC 321_ RAQNS 326_ LGSQH 331_ VSLNL 336_ SLQQE 341_ YTGKM 346_ RPVSG 351_ VLLGA 356_ VGGAG 361_ ATALV 366_ FLSFC 371_ VIFIV 376_ VRSCR 381_ KKSAR 386_ PAADV 391_ GDIGM 396_ KDANT 401_ IRGSA 406_ SQGNL 411_ TESWA 416_ DDNPR 421_ HHGLA 426_ AHSSG 431_ EEREI 436_ QYAPL 441_ SFHKG 446_ EPQDL 451_ SGQEA 456_ TNNEY 461_SEIKI
1: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)