Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
1_MVKVT 6_ FNSAL 11_ AQKEA 16_ KKDEP 21_ KSGEE 26_ ALIIP 31_ PDAVA 36_ VDCKD 41_ PDDVV 46_ PVGQR 51_ RAWCW 56_ CMCFG 61_ LAFML 66_ AGVIL 71_ GGAYL 76_ YKYFA 81_ LQPDD 86_ VYYCG 91_ IKYIK 96_ DDVIL 101_ NEPSA 106_ DAPAA 111_ LYQTI 116_ EENIK 121_ IFEEE 126_ EVEFI 131_ SVPVP 136_ EFADS 141_ DPANI 146_ VHDFN 151_ KKLTA 156_ YLDLN 161_ LDKCY 166_ VIPLN 171_ TSIVM 176_ PPRNL 181_ LELLI 186_ NIKAG 191_ TYLPQ 196_ SYLIH 201_ EHMVI 206_ TDRIE 211_ NIDHL 216_ GFFIY 221_ RLCHD 226_ KETYK 231_ LQRRE 236_ TIKGI 241_ QKREA 246_ SNCFA 251_ IRHFE 256_ NKFAV 261_ETLIC
1: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites
2: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42
3: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers