Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6)
1_MSVGV 6_ STSAP 11_ LSPTS 16_ GTSVG 21_ MSTFS 26_ IMDYV 31_ VFVLL 36_ LVLSL 41_ AIGLY 46_ HACRG 51_ WGRHT 56_ VGELL 61_ MADRK 66_ MGCLP 71_ VALSL 76_ LATFQ 81_ SAVAI 86_ LGVPS 91_ EIYRF 96_ GTQYW 101_ FLGCC 106_ YFLGL 111_ LIPAH 116_ IFIPV 121_ FYRLH 126_ LTSAY 131_ EYLEL 136_ RFNKT 141_ VRVCG 146_ TVTFI 151_ FQMVI 156_ YMGVV 161_ LYAPS 166_ LALNA 171_ VTGFD 176_ LWLSV 181_ LALGI 186_ VCTVY 191_ TALGG 196_ LKAVI 201_ WTDVF 206_ QTLVM 211_ FLGQL 216_ AVIIV 221_ GSAKV 226_ GGLGR 231_ VWAVA 236_ SQHGR 241_ ISGFE 246_ LDPDP 251_ FVRHT 256_ FWTLA 261_ FGGVF 266_ MMLSL 271_ YGVNQ 276_ AQVQR 281_ YLSSR 286_ TEKAA 291_ VLSCY 296_ AVFPF 301_ QQVSL 306_ CVGCL 311_ IGLVM 316_ FAYYQ 321_ EYPMS 326_ IQQAQ 331_ AAPDQ 336_ FVLYF 341_ VMDLL 346_ KGLPG 351_ LPGLF 356_ IACLF 361_ SGSLS 366_ TISSA 371_ FNSLA 376_ TVTME 381_ DLIRP 386_ WFPEF 391_ SEARA 396_ IMLSR 401_ GLAFG 406_ YGLLC 411_ LGMAY 416_ ISSQM 421_ GPVLQ 426_ AAISI 431_ FGMVG 436_ GPLLG 441_ LFCLG 446_ MFFPC 451_ ANPPG 456_ AVVGL 461_ LAGLV 466_ MAFWI 471_ GIGSI 476_ VTSMG 481_ SSMPP 486_ SPSNG 491_ SSFSL 496_ PTNLT 501_ VATVT 506_ TLMPL 511_ TTFSK 516_ PTGLQ 521_ RFYSL 526_ SYLWY 531_ SAHNS 536_ TTVIV 541_ VGLIV 546_ SLLTG 551_ RMRGR 556_ SLNPA 561_ TIYPV 566_ LPKLL 571_ SLLPL 576_ SCQKR 581_ LHCRS 586_ YGQDH 591_ LDTGL 596_ FPEKP 601_ RNGVL 606_ GDSRD 611_ KEAMA 616_ LDGTA 621_ YQGSS 626_STCIL
1: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983)