Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)
1_MSSTL 6_ AKIAE 11_ IEAEM 16_ ARTQK 21_ NKATA 26_ HHLGL 31_ LKARL 36_ AKLRR 41_ ELITP 46_ KGGGG 51_ GGPGE 56_ GFDVA 61_ KTGDA 66_ RIGFV 71_ GFPSV 76_ GKSTL 81_ LSNLA 86_ GVYSE 91_ VAAYE 96_ FTTLT 101_ TVPGV 106_ IRYKG 111_ AKIQL 116_ LDLPG 121_ IIEGA 126_ KDGKG 131_ RGRQV 136_ IAVAR 141_ TCNLI 146_ LIVLD 151_ VLKPL 156_ GHKKI 161_ IENEL 166_ EGFGI 171_ RLNSK 176_ PPNIG 181_ FKKKD 186_ KGGIN 191_ LTATC 196_ PQSEL 201_ DAETV 206_ KSILA 211_ EYKIH 216_ NADVT 221_ LRSDA 226_ TADDL 231_ IDVVE 236_ GNRVY 241_ IPCIY 246_ VLNKI 251_ DQISI 256_ EELDI 261_ IYKVP 266_ HCVPI 271_ SAHHR 276_ WNFDD 281_ LLEKI 286_ WDYLK 291_ LVRIY 296_ TKPKG 301_ QLPDY 306_ TSPVV 311_ LPYSR 316_ TTVED 321_ FCMKI 326_ HKNLI 331_ KEFKY 336_ ALVWG 341_ LSVKH 346_ NPQKV 351_ GKDHT 356_ LEDED 361_VIQIV
1: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639)