F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
1_MDPAE 6_ AVLQE 11_ KALKF 16_ MCSMP 21_ RSLWL 26_ GCSSL 31_ ADSMP 36_ SLRCL 41_ YNPGT 46_ GALTA 51_ FQNSS 56_ EREDC 61_ NNGEP 66_ PRKII 71_ PEKNS 76_ LRQTY 81_ NSCAR 86_ LCLNQ 91_ ETVCL 96_ ASTAM 101_ KTENC 106_ VAKTK 111_ LANGT 116_ SSMIV 121_ PKQRK 126_ LSASY 131_ EKEKE 136_ LCVKY 141_ FEQWS 146_ ESDQV 151_ EFVEH 156_ LISQM 161_ CHYQH 166_ GHINS 171_ YLKPM 176_ LQRDF 181_ ITALP 186_ ARGLD 191_ HIAEN 196_ ILSYL 201_ DAKSL 206_ CAAEL 211_ VCKEW 216_ YRVTS 221_ DGMLW 226_ KKLIE 231_ RMVRT 236_ DSLWR 241_ GLAER 246_ RGWGQ 251_ YLFKN 256_ KPPDG 261_ NAPPN 266_ SFYRA 271_ LYPKI 276_ IQDIE 281_ TIESN 286_ WRCGR 291_ HSLQR 296_ IHCRS 301_ ETSKG 306_ VYCLQ 311_ YDDQK 316_ IVSGL 321_ RDNTI 326_ KIWDK 331_ NTLEC 336_ KRILT 341_ GHTGS 346_ VLCLQ 351_ YDERV 356_ IITGS 361_ SDSTV 366_ RVWDV 371_ NTGEM 376_ LNTLI 381_ HHCEA 386_ VLHLR 391_ FNNGM 396_ MVTCS 401_ KDRSI 406_ AVWDM 411_ ASPTD 416_ ITLRR 421_ VLVGH 426_ RAAVN 431_ VVDFD 436_ DKYIV 441_ SASGD 446_ RTIKV 451_ WNTST 456_ CEFVR 461_ TLNGH 466_ KRGIA 471_ CLQYR 476_ DRLVV 481_ SGSSD 486_ NTIRL 491_ WDIEC 496_ GACLR 501_ VLEGH 506_ EELVR 511_ CIRFD 516_ NKRIV 521_ SGAYD 526_ GKIKV 531_ WDLVA 536_ ALDPR 541_ APAGT 546_ LCLRT 551_ LVEHS 556_ GRVFR 561_ LQFDE 566_ FQIVS 571_ SSHDD 576_ TILIW 581_ DFLND 586_ PAAQA 591_ EPPRS 596_PSRTY
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14603323, PubMed:14681206). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:9859996). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (PubMed:10835356, PubMed:11158290, PubMed:14673179). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564, PubMed:25704143). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:18354482, PubMed:21258371). SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:33110214, PubMed:36608670). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265)