Gene name: UST

Uniprot entry:

Q9Y2C2

Protein names:

Uronyl 2-sulfotransferase (EC 2.8.2.-)

Protein sequence:

1_MKKKQ 6_ QHPGG 11_ GADPW 16_ PHGAP 21_ MGGAP 26_ PGLGS 31_ WKRRV 36_ PLLPF 41_ LRFSL 46_ RDYGF 51_ CMATL 56_ LVFCL 61_ GSLLY 66_ QLSGG 71_ PPRFL 76_ LDLRQ 81_ YLGNS 86_ TYLDD 91_ HGPPP 96_ SKVLP 101_ FPSQV 106_ VYNRV 111_ GKCGS 116_ RTVVL 121_ LLRIL 126_ SEKHG 131_ FNLVT 136_ SDIHN 141_ KTRLT 146_ KNEQM 151_ ELIKN 156_ ISTAE 161_ QPYLF 166_ TRHVH 171_ FLNFS 176_ RFGGD 181_ QPVYI 186_ NIIRD 191_ PVNRF 196_ LSNYF 201_ FRRFG 206_ DWRGE 211_ QNHMI 216_ RTPSM 221_ RQEER 226_ YLDIN 231_ ECILE 236_ NYPEC 241_ SNPRL 246_ FYIIP 251_ YFCGQ 256_ HPRCR 261_ EPGEW 266_ ALERA 271_ KLNVN 276_ ENFLL 281_ VGILE 286_ ELEDV 291_ LLLLE 296_ RFLPH 301_ YFKGV 306_ LSIYK 311_ DPEHR 316_ KLGNM 321_ TVTVK 326_ KTVPS 331_ PEAVQ 336_ ILYQR 341_ MRYEY 346_ EFYHY 351_ VKEQF 356_ HLLKR 361_ KFGLK 366_ SHVSK 371_ PPLRP 376_ HFFIP 381_ TPLET 386_ EEPID 391_ DEEQD 396_ DEKWL 401_EDIYK

Protein annotations

Protein functions:

1: Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues in glycosaminoglycan chains (PubMed:10187838, PubMed:17227754). Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate (PubMed:10187838). Has little to no activity toward desulfated N-resulfated heparin or N-sulfoheparosan (PubMed:10187838, PubMed:17227754)