Toll-like receptor 6 (CD antigen CD286)
1_MTKDK 6_ EPIVK 11_ SFHFV 16_ CLMII 21_ IVGTR 26_ IQFSD 31_ GNEFA 36_ VDKSK 41_ RGLIH 46_ VPKDL 51_ PLKTK 56_ VLDMS 61_ QNYIA 66_ ELQVS 71_ DMSFL 76_ SELTV 81_ LRLSH 86_ NRIQL 91_ LDLSV 96_ FKFNQ 101_ DLEYL 106_ DLSHN 111_ QLQKI 116_ SCHPI 121_ VSFRH 126_ LDLSF 131_ NDFKA 136_ LPICK 141_ EFGNL 146_ SQLNF 151_ LGLSA 156_ MKLQK 161_ LDLLP 166_ IAHLH 171_ LSYIL 176_ LDLRN 181_ YYIKE 186_ NETES 191_ LQILN 196_ AKTLH 201_ LVFHP 206_ TSLFA 211_ IQVNI 216_ SVNTL 221_ GCLQL 226_ TNIKL 231_ NDDNC 236_ QVFIK 241_ FLSEL 246_ TRGST 251_ LLNFT 256_ LNHIE 261_ TTWKC 266_ LVRVF 271_ QFLWP 276_ KPVEY 281_ LNIYN 286_ LTIIE 291_ SIREE 296_ DFTYS 301_ KTTLK 306_ ALTIE 311_ HITNQ 316_ VFLFS 321_ QTALY 326_ TVFSE 331_ MNIMM 336_ LTISD 341_ TPFIH 346_ MLCPH 351_ APSTF 356_ KFLNF 361_ TQNVF 366_ TDSIF 371_ EKCST 376_ LVKLE 381_ TLILQ 386_ KNGLK 391_ DLFKV 396_ GLMTK 401_ DMPSL 406_ EILDV 411_ SWNSL 416_ ESGRH 421_ KENCT 426_ WVESI 431_ VVLNL 436_ SSNML 441_ TDSVF 446_ RCLPP 451_ RIKVL 456_ DLHSN 461_ KIKSV 466_ PKQVV 471_ KLEAL 476_ QELNV 481_ AFNSL 486_ TDLPG 491_ CGSFS 496_ SLSVL 501_ IIDHN 506_ SVSHP 511_ SADFF 516_ QSCQK 521_ MRSIK 526_ AGDNP 531_ FQCTC 536_ ELREF 541_ VKNID 546_ QVSSE 551_ VLEGW 556_ PDSYK 561_ CDYPE 566_ SYRGS 571_ PLKDF 576_ HMSEL 581_ SCNIT 586_ LLIVT 591_ IGATM 596_ LVLAV 601_ TVTSL 606_ CIYLD 611_ LPWYL 616_ RMVCQ 621_ WTQTR 626_ RRARN 631_ IPLEE 636_ LQRNL 641_ QFHAF 646_ ISYSE 651_ HDSAW 656_ VKSEL 661_ VPYLE 666_ KEDIQ 671_ ICLHE 676_ RNFVP 681_ GKSIV 686_ ENIIN 691_ CIEKS 696_ YKSIF 701_ VLSPN 706_ FVQSE 711_ WCHYE 716_ LYFAH 721_ HNLFH 726_ EGSNN 731_ LILIL 736_ LEPIP 741_ QNSIP 746_ NKYHK 751_ LKALM 756_ TQRTY 761_ LQWPK 766_ EKSKR 771_ GLFWA 776_ NIRAA 781_ FNMKL 786_ TLVTE 791_NNDVK
1: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584)