Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein)
1_MGDWM 6_ TVTDP 11_ GLSSE 16_ SKTIS 21_ QYTSE 26_ TKMSP 31_ SSLYS 36_ QQVLC 41_ SSIPL 46_ SKNVH 51_ SFFSA 56_ FCTED 61_ NIEQS 66_ ISYLD 71_ QELTT 76_ FGFPS 81_ LYEES 86_ KGKET 91_ KRELN 96_ IVAVL 101_ NCMNE 106_ LLVLQ 111_ RKNLL 116_ AQENV 121_ ETQNL 126_ KLGSD 131_ MDHLQ 136_ SCYSK 141_ LKEQL 146_ ETSRR 151_ EMIGL 156_ QERDR 161_ QLQCK 166_ NRNLH 171_ QLLKN 176_ EKDEV 181_ QKLQN 186_ IIASR 191_ ATQYN 196_ HDMKR 201_ KEREY 206_ NKLKE 211_ RLHQL 216_ VMNKK 221_ DKKIA 226_ MDILN 231_ YVGRA 236_ DGKRG 241_ SWRTG 246_ KTEAR 251_ NEDEM 256_ YKILL 261_ NDYEY 266_ RQKQI 271_ LMENA 276_ ELKKV 281_ LQQMK 286_ KEMIS 291_ LLSPQ 296_ KKKPR 301_ ERVDD 306_ STGTV 311_ ISDVE 316_ EDAGE 321_ LSRES 326_ MWDLS 331_ CETVR 336_ EQLTN 341_ SIRKQ 346_ WRILK 351_ SHVEK 356_ LDNQV 361_ SKVHL 366_ EGFND 371_ EDVIS 376_ RQDHE 381_ QETEK 386_ LELEI 391_ QQCKE 396_ MIKTQ 401_ QQLLQ 406_ QQLAT 411_ AYDDD 416_ TTSLL 421_ RDCYL 426_ LEEKE 431_ RLKEE 436_ WSLFK 441_ EQKKN 446_ FERER 451_ RSFTE 456_ AAIRL 461_ GLERK 466_ AFEEE 471_ RASWL 476_ KQQFL 481_ NMTTF 486_ DHQNS 491_ ENVKL 496_ FSAFS 501_ GSSDW 506_ DNLIV 511_ HSRQP 516_ QKKPH 521_ SVSNG 526_ SPVCM 531_ SKLTK 536_ SLPAS 541_ PSTSD 546_ FCQTR 551_ SCISE 556_ HSSIN 561_ VLNIT 566_ AEEIK 571_ PNQVG 576_ GECTN 581_ QKWSV 586_ ASRPG 591_ SQEGC 596_ YSGCS 601_ LSYTN 606_SHVEK
1: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449)