Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)
1_MGEKM 6_ AEEER 11_ FPNTT 16_ HEGFN 21_ VTLHT 26_ TLVVT 31_ TKLVL 36_ PTPGK 41_ PILPV 46_ QTGEQ 51_ AQQEE 56_ QSSGM 61_ TIFFS 66_ LLVLA 71_ ICIIL 76_ VHLLI 81_ RYRLH 86_ FLPES 91_ VAVVS 96_ LGILM 101_ GAVIK 106_ IIEFK 111_ KLANW 116_ KEEEM 121_ FRPNM 126_ FFLLL 131_ LPPII 136_ FESGY 141_ SLHKG 146_ NFFQN 151_ IGSIT 156_ LFAVF 161_ GTAIS 166_ AFVVG 171_ GGIYF 176_ LGQAD 181_ VISKL 186_ NMTDS 191_ FAFGS 196_ LISAV 201_ DPVAT 206_ IAIFN 211_ ALHVD 216_ PVLNM 221_ LVFGE 226_ SILND 231_ AVSIV 236_ LTNTA 241_ EGLTR 246_ KNMSD 251_ VSGWQ 256_ TFLQA 261_ LDYFL 266_ KMFFG 271_ SAALG 276_ TLTGL 281_ ISALV 286_ LKHID 291_ LRKTP 296_ SLEFG 301_ MMIIF 306_ AYLPY 311_ GLAEG 316_ ISLSG 321_ IMAIL 326_ FSGIV 331_ MSHYT 336_ HHNLS 341_ PVTQI 346_ LMQQT 351_ LRTVA 356_ FLCET 361_ CVFAF 366_ LGLSI 371_ FSFPH 376_ KFEIS 381_ FVIWC 386_ IVLVL 391_ FGRAV 396_ NIFPL 401_ SYLLN 406_ FFRDH 411_ KITPK 416_ MMFIM 421_ WFSGL 426_ RGAIP 431_ YALSL 436_ HLDLE 441_ PMEKR 446_ QLIGT 451_ TTIVI 456_ VLFTI 461_ LLLGG 466_ STMPL 471_ IRLMD 476_ IEDAK 481_ AHRRN 486_ KKDVN 491_ LSKTE 496_ KMGNT 501_ VESEH 506_ LSELT 511_ EEEYE 516_ AHYIR 521_ RQDLK 526_ GFVWL 531_ DAKYL 536_ NPFFT 541_ RRLTQ 546_ EDLHH 551_ GRIQM 556_ KTLTN 561_ KWYEE 566_ VRQGP 571_ SGSED 576_DEQEL
1: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (PubMed:15522866, PubMed:20719963). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity)