Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]
1_MEVVD 6_ ETEAL 11_ QRFFE 16_ GHDIN 21_ GALEP 26_ SNIDT 31_ SILEE 36_ YISKE 41_ DASDL 46_ CFPDI 51_ SAPAS 56_ SASYS 61_ HGQPA 66_ MPGSS 71_ GVHHL 76_ SPPGG 81_ GPSPG 86_ RHGPL 91_ PPPGY 96_ GTPLN 101_ CNNNN 106_ GMGAA 111_ PKPFP 116_ GGTGP 121_ PIKAE 126_ PKAPY 131_ APGTL 136_ PDSPP 141_ DSGSE 146_ AYSPQ 151_ QVNEP 156_ HLLRT 161_ ITPET 166_ LCHVG 171_ VPSRL 176_ EHPPP 181_ PPAHL 186_ PGPPP 191_ PPPPP 196_ PHYPV 201_ LQRDL 206_ YMKAE 211_ PPIPH 216_ YAAMG 221_ QGLVP 226_ TDLHH 231_ TQQSQ 236_ MLHQL 241_ LQQHG 246_ AELPT 251_ HPSKK 256_ RKHSE 261_ SPPST 266_ LNAQM 271_ LNGMI 276_ KQEPG 281_ TVTAL 286_ PLHPT 291_ RAPSP 296_ PWPPQ 301_ GPLSP 306_ GPGSL 311_ PLSIA 316_ RVQTP 321_ PWHPP 326_ GAPSP 331_ GLLQD 336_ SDSLS 341_ GSYLD 346_ PNYQS 351_ IKWQP 356_ HQQNK 361_ WATLY 366_ DANYK 371_ ELPML 376_ TYRVD 381_ ADKGF 386_ NFSVG 391_ DDAFV 396_ CQKKN 401_ HFQVT 406_ VYIGM 411_ LGEPK 416_ YVKTP 421_ EGLKP 426_ LDCFY 431_ LKLHG 436_ VKLEA 441_ LNQSI 446_ NIEQS 451_ QSDRS 456_ KRPFN 461_ PVTVN 466_ LPPEQ 471_ VTKVT 476_ VGRLH 481_ FSETT 486_ ANNMR 491_ KKGKP 496_ NPDQR 501_ YFMLV 506_ VALQA 511_ HAQNQ 516_ NYTLA 521_ AQISE 526_ RIIVR 531_ ASNPG 536_ QFESD 541_ SDVLW 546_ QRAQV 551_ PDTVF 556_ HHGRV 561_ GINTD 566_ RPDEA 571_ LVVHG 576_ NVKVM 581_ GSLMH 586_ PSDLR 591_ AKEHV 596_ QEVDT 601_ TEQLK 606_ RISRM 611_ RLVHY 616_ RYKPE 621_ FAASA 626_ GIEAT 631_ APETG 636_ VIAQE 641_ VKEIL 646_ PEAVK 651_ DTGDM 656_ VFANG 661_ KTIEN 666_ FLVVN 671_ KERIF 676_ MENVG 681_ AVKEL 686_ CKLTD 691_ NLETR 696_ IDELE 701_ RWSHK 706_ LAKLR 711_ RLDSL 716_ KSTGS 721_ SGAFS 726_ HAGSQ 731_ FSRAG 736_ SVPHK 741_ KRPPK 746_ VASKS 751_ SSVVP 756_ DQACI 761_ SQRFL 766_ QGTII 771_ ALVVV 776_ MAFSV 781_ VSMST 786_ LYVLS 791_ LRTEE 796_ DLVDT 801_ DGSFA 806_ VSTSC 811_ LLALL 816_ RPQPP 821_ GGSEA 826_ LCPWS 831_ SQSFG 836_ TTQLR 841_ QSPLT 846_ TGLPG 851_ IQPSL 856_ LLVTT 861_ SLTSS 866_ APGSA 871_ VRTLD 876_ MCSSH 881_ PCPVI 886_ CCSSP 891_ TTNPT 896_ TGPSL 901_ GPSFN 906_ PGHVL 911_ SPSPS 916_ PSTNR 921_ SGPSQ 926_ MALLP 931_ VTNIR 936_ AKSWG 941_ LSVNG 946_ IGHSK 951_ HHKSL 956_ EPLAS 961_ PAVPF 966_ PGGQG 971_ KAKNS 976_ PSLGF 981_ HGRAR 986_ RGALQ 991_ SSVGP 996_ AEPTW 1001_ AQGQS 1006_ ASLLA 1011_ EPVPS 1016_ LTSIQ 1021_ VLENS 1026_ MSITS 1031_ QYCAP 1036_ GDACR 1041_ PGNFT 1046_ YHIPV 1051_ SSGTP 1056_ LHLSL 1061_ TLQMN 1066_ SSSPV 1071_ SVVLC 1076_ SLRSK 1081_ EEPCE 1086_ EGSLP 1091_ QSLHT 1096_ HQDTQ 1101_ GTSHR 1106_ WPITI 1111_ LSFRE 1116_ FTYHF 1121_ RVALL 1126_ GQANC 1131_ SSEAL 1136_ AQPAT 1141_ DYHFH 1146_FYRLC
1: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832)
2: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage
3: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832)