GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)
1_MATLS 6_ FVFLL 11_ LGAVS 16_ WPPAS 21_ ASGQE 26_ FWPGQ 31_ SAADI 36_ LSGAA 41_ SRRRY 46_ LLYDV 51_ NPPEG 56_ FNLRR 61_ DVYIR 66_ IASLL 71_ KTLLK 76_ TEEWV 81_ LVLPP 86_ WGRLY 91_ HWQSP 96_ DIHQV 101_ RIPWS 106_ EFFDL 111_ PSLNK 116_ NIPVI 121_ EYEQF 126_ IAESG 131_ GPFID 136_ QVYVL 141_ QSYAE 146_ GWKEG 151_ TWEEK 156_ VDERP 161_ CIDQL 166_ LYSQD 171_ KHEYY 176_ RGWFW 181_ GYEET 186_ RGLNV 191_ SCLSV 196_ QGSAS 201_ IVAPL 206_ LLRNT 211_ SARSV 216_ MLDRA 221_ ENLLH 226_ DHYGG 231_ KEYWD 236_ TRRSM 241_ VFARH 246_ LREVG 251_ DEFRS 256_ RHLNS 261_ TDDAD 266_ RIPFQ 271_ EDWMK 276_ MKVKL 281_ GSALG 286_ GPYLG 291_ VHLRR 296_ KDFIW 301_ GHRQD 306_ VPSLE 311_ GAVRK 316_ IRSLM 321_ KTHRL 326_ DKVFV 331_ ATDAV 336_ RKEYE 341_ ELKKL 346_ LPEMV 351_ RFEPT 356_ WEELE 361_ LYKDG 366_ GVAII 371_ DQWIC 376_ AHARF 381_ FIGTS 386_ VSTFS 391_ FRIHE 396_ EREIL 401_ GLDPK 406_ TTYNR 411_ FCGDQ 416_ EKACE 421_QPTHW
1: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395588, PubMed:17395589). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity)