Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)
1_MELFQ 6_ AKDHY 11_ ILQQG 16_ ERALW 21_ CSRRD 26_ GGLQL 31_ RPATD 36_ LLLAW 41_ NPICL 46_ GLVEG 51_ VIGKI 56_ QLHSD 61_ LPWWL 66_ ILIRQ 71_ KALVG 76_ KLPGD 81_ HEVCK 86_ VTKIA 91_ VLSLS 96_ EMEPQ 101_ DLELE 106_ LCKKH 111_ HFGIN 116_ KPEKI 121_ IPSPD 126_ DSKFL 131_ LKTFT 136_ HIKSN 141_ VSAPN 146_ KKKVK 151_ ESKEK 156_ EKLER 161_ RLLEE 166_ LLKMF 171_ MDSES 176_ FYYSL 181_ TYDLT 186_ NSVQR 191_ QSTGE 196_ RDGRP 201_ LWQKV 206_ DDRFF 211_ WNKYM 216_ IQDLT 221_ EIGTP 226_ DVDFW 231_ IIPMI 236_ QGFVQ 241_ IEELV 246_ VNYTE 251_ SSDDE 256_ KSSPE 261_ TPPQE 266_ STCVD 271_ DIHPR 276_ FLVAL 281_ ISRRS 286_ RHRAG 291_ MRYKR 296_ RGVDK 301_ NGNVA 306_ NYVET 311_ EQLIH 316_ VHNHT 321_ LSFVQ 326_ TRGSV 331_ PVFWS 336_ QVGYR 341_ YNPRP 346_ RLDRS 351_ EKETV 356_ AYFCA 361_ HFEEQ 366_ LNIYK 371_ KQVII 376_ NLVDQ 381_ AGREK 386_ IIGDA 391_ YLKQV 396_ LLFNN 401_ SHLTY 406_ VSFDF 411_ HEHCR 416_ GMKFE 421_ NVQTL 426_ TDAIY 431_ DIILD 436_ MKWCW 441_ VDEAG 446_ VICKQ 451_ EGIFR 456_ VNCMD 461_ CLDRT 466_ NVVQA 471_ AIARV 476_ VMEQQ 481_ LKKLG 486_ VMPPE 491_ QPLPV 496_ KCNRI 501_ YQIMW 506_ ANNGD 511_ SISRQ 516_ YAGTA 521_ ALKGD 526_ FTRTG 531_ ERKLA 536_ GVMKD 541_ GVNSA 546_ NRYYL 551_ NRFKD 556_ AYRQA 561_ VIDLM 566_ QGIPV 571_ TEDLY 576_ SIFTK 581_ EKEHE 586_ ALHKE 591_ NQRSH 596_ QELIS 601_ QLLQS 606_ YMKLL 611_ LPDDE 616_ KFHGG 621_ WALID 626_ CDPSL 631_ IDATH 636_ RDVDV 641_ LLLLS 646_ NSAYY 651_ VAYYD 656_ DEVDK 661_ VNQYQ 666_ RLSLE 671_ NLEKI 676_ EIGPE 681_ PTLFG 686_ KPKFS 691_ CMRLH 696_ YRYKE 701_ ASGYF 706_ HTLRA 711_ VMRNP 716_ EEDGK 721_ DTLQC 726_ IAEML 731_ QITKQ 736_ AMGSD 741_ LPIIE 746_ KKLER 751_ KSSKP 756_ HEDII 761_ GIRSQ 766_ NQGSL 771_ AQGKN 776_ FLMSK 781_ FSSLN 786_ QKVKQ 791_ TKSNV 796_ NIGNL 801_ RKLGN 806_ FTKPE 811_ MKVNF 816_ LKPNL 821_ KVNLW 826_ KSDSS 831_ LETME 836_ NTGVM 841_ DKVQA 846_ ESDGD 851_ MSSDN 856_ DSYHS 861_ DEFLT 866_ NSKSD 871_ EDRQL 876_ ANSLE 881_ SVGPI 886_ DYVLP 891_ SCGII 896_ ASAPR 901_ LGSRS 906_ QSLSS 911_ TDSSV 916_ HAPSE 921_ ITVAH 926_ GSGLG 931_ KGQES 936_ PLKKS 941_ PSAGD 946_ VHILT 951_ GFAKP 956_ MDIYC 961_ HRFVQ 966_ DAQNK 971_ VTHLS 976_ ETRSV 981_ SQQAS 986_ QERNQ 991_ MTNQV 996_ SNETQ 1001_ SESTE 1006_ QTPSR 1011_ PSQLD 1016_ VSLSA 1021_ TGPQF 1026_ LSVEP 1031_ AHSVA 1036_ SQKTP 1041_ TSASS 1046_ MLELE 1051_ TGLHV 1056_ TPSPS 1061_ ESSSS 1066_ RAVSP 1071_ FAKIR 1076_ SSMVQ 1081_ VASIT 1086_ QAGLT 1091_ HGINF 1096_ AVSKV 1101_ QKSPP 1106_ EPEII 1111_ NQVQQ 1116_ NELKK 1121_ MFIQC 1126_QTRII
1: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity)