Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
1_MATAR 6_ TFGPE 11_ REAEP 16_ AKEAR 21_ VVGSE 26_ LVDTY 31_ TVYII 36_ QVTDG 41_ SHEWT 46_ VKHRY 51_ SDFHD 56_ LHEKL 61_ VAERK 66_ IDKNL 71_ LPPKK 76_ IIGKN 81_ SRSLV 86_ EKREK 91_ DLEVY 96_ LQKLL 101_ AAFPG 106_ VTPRV 111_ LAHFL 116_ HFHFY 121_ EINGI 126_ TAALA 131_ EELFE 136_ KGEQL 141_ LGAGE 146_ VFAIG 151_ PLQLY 156_ AVTEQ 161_ LQQGK 166_ PTCAS 171_ GDAKT 176_ DLGHI 181_ LDFTC 186_ RLKYL 191_ KVSGT 196_ EGPFG 201_ TSNIQ 206_ EQLLP 211_ FDLSI 216_ FKSLH 221_ QVEIS 226_ HCDAK 231_ HIRGL 236_ VASKP 241_ TLATL 246_ SVRFS 251_ ATSMK 256_ EVLVP 261_ EASEF 266_ DEWEP 271_ EGTTL 276_ EGPVT 281_ AVIPT 286_ WQALT 291_ TLDLS 296_ HNSVS 301_ EIDES 306_ VKLIP 311_ KIEFL 316_ DLSHN 321_ GLLVV 326_ DNLQH 331_ LYNLV 336_ HLDLS 341_ YNKLS 346_ SLEGL 351_ HTKLG 356_ NIKTL 361_ NLAGN 366_ LLESL 371_ SGLHK 376_ LYSLV 381_ NLDLR 386_ DNRIE 391_ QMEEV 396_ RSIGS 401_ LPCLE 406_ HVSLL 411_ NNPLS 416_ IIPDY 421_ RTKVL 426_ AQFGE 431_ RASEV 436_ CLDDT 441_ VTTEK 446_ ELDTV 451_ EVLKA 456_ IQKAK 461_ EVKSK 466_ LSNPE 471_ KKGGE 476_ DSRLS 481_ AAPCI 486_ RPSSS 491_ PPTVA 496_ PASAS 501_ LPQPI 506_ LSNQG 511_ IMFVQ 516_ EEALA 521_ SSLSS 526_ TDSLT 531_ PEHQP 536_ IAQGC 541_ SDSLE 546_ SIPAG 551_ QAASD 556_ DLRDV 561_ PGAVG 566_ GASPE 571_ HAEPE 576_ VQVVP 581_ GSGQI 586_ IFLPF 591_ TCIGY 596_ TATNQ 601_ DFIQR 606_ LSTLI 611_ RQAIE 616_ RQLPA 621_ WIEAA 626_ NQREE 631_ GQGEQ 636_ GEEED 641_ EEEEE 646_ EEDVA 651_ ENRYF 656_ EMGPP 661_ DVEEE 666_ EGGGQ 671_ GEEEE 676_ EEEED 681_ EEAEE 686_ ERLAL 691_ EWALG 696_ ADEDF 701_ LLEHI 706_ RILKV 711_ LWCFL 716_ IHVQG 721_ SIRQF 726_ AACLV 731_ LTDFG 736_ IAVFE 741_ IPHQE 746_ SRGSS 751_ QHILS 756_ SLRFV 761_ FCFPH 766_ GDLTE 771_ FGFLM 776_ PELCL 781_ VLKVR 786_ HSENT 791_ LFIIS 796_ DAANL 801_ HEFHA 806_ DLRSC 811_ FAPQH 816_ MAMLC 821_ SPILY 826_ GSHTS 831_ LQEFL 836_ RQLLT 841_ FYKVA 846_ GGCQE 851_ RSQGC 856_ FPVYL 861_ VYSDK 866_ RMVQT 871_ AAGDY 876_ SGNIE 881_ WASCT 886_ LCSAV 891_ RRSCC 896_ APSEA 901_ VKSAA 906_ IPYWL 911_ LLTPQ 916_ HLNVI 921_ KADFN 926_ PMPNR 931_ GTHNC 936_ RNRNS 941_ FKLSR 946_ VPLST 951_ VLLDP 956_ TRSCT 961_ QPRGA 966_ FADGH 971_ VLELL 976_ VGYRF 981_ VTAIF 986_ VLPHE 991_ KFHFL 996_ RVYNQ 1001_ LRASL 1006_ QDLKT 1011_ VVIAK 1016_ TPGTG 1021_ GSPQG 1026_ SFADG 1031_ QPAER 1036_ RASND 1041_ QRPQE 1046_ VPAEA 1051_ LAPAP 1056_ AEVPA 1061_ PAPAA 1066_ ASASG 1071_ PAKTP 1076_ APAEA 1081_ STSAL 1086_ VPEET 1091_ PVEAP 1096_ APPPA 1101_ EAPAQ 1106_ YPSEH 1111_ LIQAT 1116_ SEENQ 1121_ IPSHL 1126_ PACPS 1131_ LRHVA 1136_ SLRGS 1141_ AIIEL 1146_ FHSSI 1151_ AEVEN 1156_ EELRH 1161_ LMWSS 1166_ VVFYQ 1171_ TPGLE 1176_ VTACV 1181_ LLSTK 1186_ AVYFV 1191_ LHDGL 1196_ RRYFS 1201_ EPLQD 1206_ FWHQK 1211_ NTDYN 1216_ NSPFH 1221_ ISQCF 1226_ VLKLS 1231_ DLQSV 1236_ NVGLF 1241_ DQHFR 1246_ LTGST 1251_ PMQVV 1256_ TCLTR 1261_ DSYLT 1266_ HCFLQ 1271_ HLMVV 1276_ LSSLE 1281_ RTPSP 1286_ EPVDK 1291_ DFYSE 1296_ FGNKT 1301_ TGKME 1306_ NYELI 1311_ HSSRV 1316_ KFTYP 1321_ SEEEI 1326_ GDLTF 1331_ TVAQK 1336_ MAEPE 1341_ KAPAL 1346_ SILLY 1351_ VQAFQ 1356_ VGMPP 1361_ PGCCR 1366_ GPLRP 1371_ KTLLL 1376_ TSSEI 1381_ FLLDE 1386_ DCVHY 1391_ PLPEF 1396_ AKEPP 1401_ QRDRY 1406_ RLDDG 1411_ RRVRD 1416_ LDRVL 1421_ MGYQT 1426_ YPQAL 1431_ TLVFD 1436_ DVQGH 1441_ DLMGS 1446_ VTLDH 1451_ FGEVP 1456_ GGPAR 1461_ ASQGR 1466_ EVQWQ 1471_ VFVPS 1476_ AESRE 1481_ KLISL 1486_ LARQW 1491_ EALCG 1496_RELPV
1: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Also inhibits LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures