1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1)
1_MATDD 6_ KTSPT 11_ LDSAN 16_ DLPRS 21_ PTSPS 26_ HLTHF 31_ KPLTP 36_ DQDEP 41_ PFKSA 46_ YSSFV 51_ NLFRF 56_ NKERA 61_ EGGQG 66_ EQQPL 71_ SGSWT 76_ SPQLP 81_ SRTQS 86_ VRSPT 91_ PYKKQ 96_ LNEEL 101_ QRRSS 106_ ALDTR 111_ RKAEP 116_ TFGGH 121_ DPRTA 126_ VQLRS 131_ LSTVL 136_ KRLKE 141_ IMEGK 146_ SQDSD 151_ LKQYW 156_ MPDSQ 161_ CKECY 166_ DCSEK 171_ FTTFR 176_ RRHHC 181_ RLCGQ 186_ IFCSR 191_ CCNQE 196_ IPGKF 201_ MGYTG 206_ DLRAC 211_ TYCRK 216_ IALSY 221_ AHSTD 226_ SNSIG 231_ EDLNA 236_ LSDSA 241_ CSVSV 246_ LDPSE 251_ PRTPV 256_ GSRKA 261_ SRNIF 266_ LEDDL 271_ AWQSL 276_ IHPDS 281_ SNTPL 286_ STRLV 291_ SVQED 296_ AGKSP 301_ ARNRS 306_ ASITN 311_ LSLDR 316_ SGSPM 321_ VPSYE 326_ TSVSP 331_ QANRT 336_ YVRTE 341_ TTEDE 346_ RKILL 351_ DSVQL 356_ KDLWK 361_ KICHH 366_ SSGME 371_ FQDHR 376_ YWLRT 381_ HPNCI 386_ VGKEL 391_ VNWLI 396_ RNGHI 401_ ATRAQ 406_ AIAIG 411_ QAMVD 416_ GRWLD 421_ CVSHH 426_ DQLFR 431_ DEYAL 436_ YRPLQ 441_ STEFS 446_ ETPSP 451_ DSDSV 456_ NSVEG 461_ HSEPS 466_ WFKDI 471_ KFDDS 476_ DTEQI 481_ AEEGD 486_ DNLAN 491_ SASPS 496_ KRTSV 501_ SSFQS 506_ TVDSD 511_ SAASI 516_ SLNVE 521_ LDNVN 526_ FHIKK 531_ PSKYP 536_ HVPPH 541_ PADQK 546_ EYLIS 551_ DTGGQ 556_ QLSIS 561_ DAFIK 566_ ESLFN 571_ RRVEE 576_ KSKEL 581_ PFTPL 586_ GWHHN 591_ NLELL 596_ REENG 601_ EKQAM 606_ ERLLS 611_ ANHNH 616_ MMALL 621_ QQLLH 626_ SDSLS 631_ SSWRD 636_ IIVSL 641_ VCQVV 646_ QTVRP 651_ DVKNQ 656_ DDDMD 661_ IRQFV 666_ HIKKI 671_ PGGKK 676_ FDSVV 681_ VNGFV 686_ CTKNI 691_ AHKKM 696_ SSCIK 701_ NPKIL 706_ LLKCS 711_ IEYLY 716_ REETK 721_ FTCID 726_ PIVLQ 731_ EREFL 736_ KNYVQ 741_ RIVDV 746_ RPTLV 751_ LVEKT 756_ VSRIA 761_ QDMLL 766_ EHGIT 771_ LVINV 776_ KSQVL 781_ ERISR 786_ MTQGD 791_ LVMSM 796_ DQLLT 801_ KPHLG 806_ TCHKF 811_ YMQIF 816_ QLPNE 821_ QTKTL 826_ MFFEG 831_ CPQHL 836_ GCTIK 841_ LRGGS 846_ DYELA 851_ RVKEI 856_ LIFMI 861_ CVAYH 866_ SQLEI 871_ SFLMD 876_ EFAMP 881_ PTLMQ 886_ NPSFH 891_ SLIEG 896_ RGHEG 901_ AVQEQ 906_ YGGGS 911_ IPWDP 916_ DIPPE 921_ SLPCD 926_ DSSLL 931_ ELRIV 936_ FEKGE 941_ QENKN 946_ LPQAV 951_ ASVKH 956_ QEHST 961_ TACPA 966_ GLPCA 971_ FFAPV 976_ PESLL 981_ PLPVD 986_ DQQDA 991_ LGSEQ 996_ PETLQ 1001_ QTVVL 1006_ QDPKS 1011_ QIRAF 1016_ RDPLQ 1021_ DDTGL 1026_ YVTEE 1031_ VTSSE 1036_ DKRKT 1041_ YSLAF 1046_ KQELK 1051_ DVILC 1056_ ISPVI 1061_ TFREP 1066_ FLLTE 1071_ KGMRC 1076_ STRDY 1081_ FAEQV 1086_ YWSPL 1091_ LNKEF 1096_ KEMEN 1101_ RRKKQ 1106_ LLRDL 1111_ SGLQG 1116_ MNGSI 1121_ QAKSI 1126_ QVLPS 1131_ HELVS 1136_ TRIAE 1141_ HLGDS 1146_ QSLGR 1151_ MLADY 1156_ RARGG 1161_ RIQPK 1166_ NSDPF 1171_ AHSKD 1176_ ASSTS 1181_ SGQSG 1186_ SKNEG 1191_ DEERG 1196_ LILSD 1201_ AVWST 1206_ KVDCL 1211_ NPINH 1216_ QRLCV 1221_ LFSSS 1226_ SAQSS 1231_ NAPSA 1236_ CVSPW 1241_ IVTME 1246_ FYGKN 1251_ DLTLG 1256_ IFLER 1261_ YCFRP 1266_ SYQCP 1271_ SMFCD 1276_ TPMVH 1281_ HIRRF 1286_ VHGQG 1291_ CVQII 1296_ LKELD 1301_ SPVPG 1306_ YQHTI 1311_ LTYSW 1316_ CRICK 1321_ QVTPV 1326_ VALSN 1331_ ESWSM 1336_ SFAKY 1341_ LELRF 1346_ YGHQY 1351_ TRRAN 1356_ AEPCG 1361_ HSIHH 1366_ DYHQY 1371_ FSYNQ 1376_ MVASF 1381_ SYSPI 1386_ RLLEV 1391_ CVPLP 1396_ KIFIK 1401_ RQAPL 1406_ KVSLL 1411_ QDLKD 1416_ FFQKV 1421_ SQVYV 1426_ AIDER 1431_ LASLK 1436_ TDTFS 1441_ KTREE 1446_ KMEDI 1451_ FAQKE 1456_ MEEGE 1461_ FKNWI 1466_ EKMQA 1471_ RLMSS 1476_ SVDTP 1481_ QQLQS 1486_ VFESL 1491_ IAKKQ 1496_ SLCEV 1501_ LQAWN 1506_ NRLQD 1511_ LFQQE 1516_ KGRKR 1521_ PSVPP 1526_ SPGRL 1531_ RQGEE 1536_ SKISA 1541_ MDASP 1546_ RNISP 1551_ GLQNG 1556_ EKEDR 1561_ FLTTL 1566_ SSQSS 1571_ TSSTH 1576_ LQLPT 1581_ PPEVM 1586_ SEQSV 1591_ GGPPE 1596_ LDTAS 1601_ SSEDV 1606_ FDGHL 1611_ LGSTD 1616_ SQVKE 1621_ KSTMK 1626_ AIFAN 1631_ LLPGN 1636_ SYNPI 1641_ PFPFD 1646_ PDKHY 1651_ LMYEH 1656_ ERVPI 1661_ AVCEK 1666_ EPSSI 1671_ IAFAL 1676_ SCKEY 1681_ RNALE 1686_ ELSKA 1691_ TQWNS 1696_ AEEGL 1701_ PTNST 1706_ SDSRP 1711_ KSSSP 1716_ IRLPE 1721_ MSGGQ 1726_ TNRTT 1731_ ETEPQ 1736_ PTKKA 1741_ SGMLS 1746_ FFRGT 1751_ AGKSP 1756_ DLSSQ 1761_ KRETL 1766_ RGADS 1771_ AYYQV 1776_ GQTGK 1781_ EGTEN 1786_ QGVEP 1791_ QDEVD 1796_ GGDTQ 1801_ KKQLI 1806_ NPHVE 1811_ LQFSD 1816_ ANAKF 1821_ YCRLY 1826_ YAGEF 1831_ HKMRE 1836_ VILDS 1841_ SEEDF 1846_ IRSLS 1851_ HSSPW 1856_ QARGG 1861_ KSGAA 1866_ FYATE 1871_ DDRFI 1876_ LKQMP 1881_ RLEVQ 1886_ SFLDF 1891_ APHYF 1896_ NYITN 1901_ AVQQK 1906_ RPTAL 1911_ AKILG 1916_ VYRIG 1921_ YKNSQ 1926_ NNTEK 1931_ KLDLL 1936_ VMENL 1941_ FYGRK 1946_ MAQVF 1951_ DLKGS 1956_ LRNRN 1961_ VKTDT 1966_ GKESC 1971_ DVVLL 1976_ DENLL 1981_ KMVRD 1986_ NPLYI 1991_ RSHSK 1996_ AVLRT 2001_ SIHSD 2006_ SHFLS 2011_ SHLII 2016_ DYSLL 2021_ VGRDD 2026_ TSNEL 2031_ VVGII 2036_ DYIRT 2041_ FTWDK 2046_ KLEMV 2051_ VKSTG 2056_ ILGGQ 2061_ GKMPT 2066_ VVSPE 2071_ LYRTR 2076_ FCEAM 2081_ DKYFL 2086_ MVPDH 2091_WTGLG
1: Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029)
2: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis