Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
1_MRTLE 6_ DSSGT 11_ VLHRL 16_ IQEQL 21_ RYGNL 26_ TETRT 31_ LLAIQ 36_ QQALR 41_ GGAGT 46_ GGTGS 51_ PQASL 56_ EILAP 61_ EDSQV 66_ LQQAT 71_ RQEPQ 76_ GQEHQ 81_ GGENH 86_ LAENT 91_ LYRLC 96_ PQPSK 101_ GEELP 106_ TYEEA 111_ KAHSQ 116_ YYAAQ 121_ QAGTR 126_ PHAGD 131_ RDPRG 136_ APGGS 141_ RRQDE 146_ ALREL 151_ RHGHV 156_ RSLSE 161_ RLLQL 166_ SLERN 171_ GARAP 176_ SHMSS 181_ SHSFP 186_ QLARN 191_ QQGPP 196_ LRGPP 201_ AEGPE 206_ SRGPP 211_ PQYPH 216_ VVLAH 221_ ETTTA 226_ VTDPR 231_ YRARG 236_ SPHFQ 241_ HAEVR 246_ ILQAQ 251_ VPPVF 256_ LQQQQ 261_ QYQYL 266_ QQSQE 271_ HPPPP 276_ HPAAL 281_ GHGPL 286_ SSLSP 291_ PAVEG 296_ PVSAQ 301_ ASSAT 306_ SGSAH 311_ LAQME 316_ AVLRE 321_ NARLQ 326_ RDNER 331_ LQREL 336_ ESSAE 341_ KAGRI 346_ EKLES 351_ EIQRL 356_ SEAHE 361_ SLTRA 366_ SSKRE 371_ ALEKT 376_ MRNKM 381_ DSEMR 386_ RLQDF 391_ NRDLR 396_ ERLES 401_ ANRRL 406_ ASKTQ 411_ EAQAG 416_ SQDMV 421_ AKLLA 426_ QSYEQ 431_ QQEQE 436_ KLERE 441_ MALLR 446_ GAIED 451_ QRRRA 456_ ELLEQ 461_ ALGNA 466_ QGRAA 471_ RAEEE 476_ LRKKQ 481_ AYVEK 486_ VERLQ 491_ QALGQ 496_ LQAAC 501_ EKREQ 506_ LELRL 511_ RTRLE 516_ QELKA 521_ LRAQQ 526_ RQAGA 531_ PGGSS 536_ GSGGS 541_ PELSA 546_ LRLSE 551_ QLREK 556_ EEQIL 561_ ALEAD 566_ MTKWE 571_ QKYLE 576_ ERAMR 581_ QFAMD 586_ AAATA 591_ AAQRD 596_ TTLIR 601_ HSPQP 606_ SPSSS 611_ FNEGL 616_ LTGGH 621_ RHQEM 626_ ESRLK 631_ VLHAQ 636_ ILEKD 641_ AVIKV 646_ LQQRS 651_ RRDPG 656_ KAIQG 661_ SLRPA 666_ KSVPS 671_ VFAAA 676_ AAGTQ 681_ GWQGL 686_ SSSER 691_ QTADA 696_ PARLT 701_ TDRAP 706_ TEEPV 711_ VTAPP 716_ AAHAK 721_ HGSRD 726_ GSTQT 731_ EGPPD 736_ STSTC 741_ LPPEP 746_ DSLLG 751_ CSSSQ 756_ RAASL 761_ DSVAT 766_ SRVQD 771_LSDMV
1: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells